drugset / Trial / NCT07600775

A Clinical Trial of MK-8527 and Rifampin in Adult Participants With Latent Tuberculosis Infection (MK-8527-019)

NCT07600775

Phase 1 Not yet recruiting 14 enrolled Merck Sharp & Dohme LLC
NaSingle-groupOpen-labelTreatment

Summary

Researchers are studying MK-8527, a new medicine for preventing HIV-1 (human immunodeficiency virus type 1) infection and want to learn if MK-8527 can be given together with rifampin. Rifampin is commonly used to treat people with latent tuberculosis infection (LTBI). The main goal of this study is to learn what happens to MK-8527 in the body over time when given with and without the medication rifampin in participants with LTBI.

Timeline

Start
2026-07-20
Primary completion
2027-01-19
Completion
2027-01-19

Drugs

EvaluationDrugModalityDoseRoute
Subject MK-8527 Small molecule Oral
Subject Rifampin Small molecule Oral