drugset / Trial / NCT07602855

A Study of Risvutatug Rezetecan in Combination With Ivonescimab in Participants With Advanced Solid Tumors (EMBOLD PanTumour-103)

NCT07602855 ↗

Phase 1/2 Recruiting 184 enrolled GlaxoSmithKline
NaSequentialOpen-labelTreatment

Summary

This is an early-phase clinical study investigating a new combination treatment, Risvutatug rezetecan (Ris-Rez) given with ivonescimab for adults with advanced solid cancers. The study aims to determine: * What dose(s) of Ris-Rez given with ivonescimab is safe and what are the side effects? * How does the body handle the drug(s)? * What dose of Ris-Rez given with ivonescimab may work best and can improve the treatment of cancer?

Timeline

Start
2026-09-09
Primary completion
2029-06-22
Completion
2029-12-24

Drugs

EvaluationDrugModalityDoseRoute
Subject Ivonescimab Monoclonal antibody — —
Subject Risvutatug rezetecan Unknown — —

Indications