rhTNK-tPA for Acute Ischemic Stroke Under Simplified Imaging in the Extended Time Window

Summary

The PEARL-SIMPLIFIED trial is a multicenter, prospective, randomized controlled, open-label, blinded-endpoint study. It aims to evaluate the efficacy and safety of intravenous tenecteplase (TNK) in patients with acute ischemic stroke (AIS) presenting in the extended 4.5-24 hour window, using a simplified imaging selection strategy based solely on non-contrast CT (NCCT).

Timeline

Start

2026-08-01

Primary completion

2028-12-01

Completion

2028-12-01

Drugs

Indications