drugset / Trial / NCT07619339

A Study of Tepotinib and Ivonescimab in People With Non-Small Cell Lung Cancer

NCT07619339

NaSingle-groupOpen-labelTreatment

Summary

The researchers are doing this study to find out whether the combination of tepotinib and ivonescimab is a safe and effective treatment for people with non-small cell lung cancer (NSCLC) that is positive for METex14 skipping. The researchers will test up to two different doses of tepotinib in combination with ivonescimab to find the best dose of tepotinib that causes few or mild side effects in participants.

Timeline

Start
2026-05-27
Primary completion
2029-05
Completion
2029-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Ivonescimab Monoclonal antibody Intravenous
Subject Tepotinib Small molecule 225 mg Oral
Subject Tepotinib Small molecule 450 mg Oral