To Evaluate Efficacy of Monotherapy of Oxcarbazepine Versus Combination of Gabapentin With Oxcarbazepine in the Management of Trigeminal Neuralgia

Summary

ABSTRACT: Objective: This study evaluates the effectiveness of oxcarbazepine monotherapy with the combination of gabapentin and oxcarbazepine in managing trigeminal neuralgia(TN). Methods: A prospective observational study was conducted at Rehman College of Dentistry for the duration of one year, i.e., from 1st May 2023 till May 2024. A total of 44 patients, fulfilling inclusion criteria, were included.Half were given monotherapy with oxcarbazepine (300 mg twice daily) and half were given combination therapy with gabapentin (100 mg daily) plus oxcarbazepine. Pain was evaluated utilizing the Visual Analogue Scale (VAS) at baseline, 2 weeks, and 2 months. SPSS software version 26 was used for statistical analysis. KEYWORDS: Combination Therapy, Gabapentin, Monotherapy, Oxcarbazepine, Trigeminal Neuralgia, Visual Analogue Scale.

Timeline

Start

2023-05-01

Primary completion

2024-05-01

Completion

2024-05-01

Publications

• Background Cheshire WP Jr. Defining the role for gabapentin in the treatment of trigeminal neuralgia: a retrospective study. J Pain. 2002 Apr;3(2):137-42. doi: 10.1054/jpai.2002.122944.
• Background Texakalidis P, Xenos D, Tora MS, Wetzel JS, Boulis NM. Comparative safety and efficacy of percutaneous approaches for the treatment of trigeminal neuralgia: A systematic review and meta-analysis. Clin Neurol Neurosurg. 2019 Jul;182:112-122. doi: 10.1016/j.clineuro.2019.05.011. Epub 2019 May 14.
• Background Das B, Saha SP. Trigeminal neuralgia: current concepts and management. J Indian Med Assoc. 2001 Dec;99(12):704-9.
• Background Ishikawa R, Iseki M. [Pharmacological Treatment of Trigeminal Neuralgia]. No Shinkei Geka. 2024 Jan;52(1):63-69. doi: 10.11477/mf.1436204880. Japanese.
• Background Lee JY, Lee GH, Yi SH, Sim WS, Kim BW, Park HJ. Non-Surgical Treatments of Trigeminal Neuralgia from the Perspective of a Pain Physician: A Narrative Review. Biomedicines. 2023 Aug 21;11(8):2315. doi: 10.3390/biomedicines11082315.

Drugs

Indications

No indication recorded.