drugset / Trial / NCT07630077

Trastuzumab Rezetecan(SHR-A1811) Combined With Ivonescimab (AK112) in Locally Advanced or Metastatic Non-small Cell Lung Cancer Harboring HER2 Gene Abnormalities

NCT07630077

Phase 2 Not yet recruiting 30 enrolled Sun Yat-sen University
NaSingle-groupOpen-labelTreatment

Summary

This is a phase II trial in patients with locally advanced or metastatic non-small cell lung cancer harboring HER2 gene abnormalities (amplification or overexpression)with a performance status of 0 to1 who are planned to receive first-line treatment or who have falied the first-line treatment

Timeline

Start
2026-07-01
Primary completion
2027-07-01
Completion
2028-07-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Ivonescimab Monoclonal antibody 20 mg/kg Intravenous
Subject Trastuzumab Rezetecan Monoclonal antibody 4.8 mg/kg Intravenous