drugset / Trial / NCT07643493

CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance

NCT07643493

Phase 4 Not yet recruiting 80 enrolled David Dornbos
RandomizedParallel-groupOpen-labelTreatment

Summary

The study aims to investigate the effect of continuous tPA irrigation into the ventricles. Investigators believe it may be superior to the traditional every 8-hour bolus dosing and continuous isotonic solution irrigation alone. The protocol plans to analyze blood clearance and functional outcomes in the patients.

Timeline

Start
2026-07-13
Primary completion
2028-05-31
Completion
2029-05-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Alteplase Protein / enzyme biologic 4 mg Intrathecal
Subject Alteplase Protein / enzyme biologic 6 mg Intrathecal