drugset / Trial / NCT07643493
CleaRRAflow: Isotonic Solution vs. TPA for IVH Clearance
RandomizedParallel-groupOpen-labelTreatment
Summary
The study aims to investigate the effect of continuous tPA irrigation into the ventricles. Investigators believe it may be superior to the traditional every 8-hour bolus dosing and continuous isotonic solution irrigation alone. The protocol plans to analyze blood clearance and functional outcomes in the patients.
Timeline
- Start
- 2026-07-13
- Primary completion
- 2028-05-31
- Completion
- 2029-05-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Alteplase | Protein / enzyme biologic | 4 mg | Intrathecal |
| Subject | Alteplase | Protein / enzyme biologic | 6 mg | Intrathecal |