Effect of GnRH Agonist in FET

Phase 1/2 Not yet recruiting 122 enrolled Assiut University Woman's Health University Hospital, Egypt · collab

RandomizedParallel-groupSingle-blindOther

Summary

To evaluate the impact of single dose GnRH agonist administration as luteal phase support on pregnancy outcomes in frozen ICSI cycle

Timeline

Start: 2026-08-01
Primary completion: 2027-08-01
Completion: 2028-08-01

Outcome

Missed primary endpoint

paper the difference of 12.1 percentage points in the live births rate (40.7% vs 28.6%) between the two groups, however, is statistically insignificant. PMID 37361538 ↗

Publications

Results Liu Y, Huang K, Chen C, Wen L, Lei M, Guo Y, Tang B. Effect of luteal-phase GnRH agonist on frozen-thawed embryo transfer during artificial cycles: a randomised clinical pilot study. Front Endocrinol (Lausanne). 2023 Jun 9;14:1098576. doi: 10.3389/fendo.2023.1098576. eCollection 2023.
Results Li S, Li Y. Administration of a GnRH agonist during the luteal phase frozen-thawed embryo transfer cycles: a meta-analysis. Gynecol Endocrinol. 2018 Nov;34(11):920-924. doi: 10.1080/09513590.2018.1480714. Epub 2018 Jul 11.
Results Chang WS, Lin PH, Li CJ, Chern CU, Chen YC, Lin LT, Tsui KH. Additional single dose GnRH agonist during luteal phase support may improve live birth rate in GnRHa-HRT frozen-thawed embryo transfer cycle: a retrospective cohort study. BMC Pregnancy Childbirth. 2023 Mar 14;23(1):174. doi: 10.1186/s12884-023-05491-y.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Triptorelin	Other / unclassified	0.1 mg	Subcutaneous

Indications

No indication recorded.