drugset / Trial / NCT07653438

In Vivo Fluorescence Molecular Bronchoscopy of Durvalumab-680LT in Patients With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) After Chemoradiotherapy

NCT07653438 ↗

Phase 2 Not yet recruiting 20 enrolled University Medical Center Groningen
Non-randomizedSequentialOpen-labelDiagnostic

Summary

PulmoPrint is a clinical study at the University Medical Center Groningen (UMCG) that investigates why some patients with unresectable stage III lung cancer don't respond to immunotherapy after chemoradiotherapy. To do this, a small dose of a fluorescently labeled version of the immunotherapy drug durvalumab is given via an intravenous (IV) drip, after which a bronchoscopy is performed to visualize where and how much of the drug reaches the tumor and lymph nodes - before the actual durvalumab treatment starts.

Timeline

Start
2026-09-01
Primary completion
2028-03-01
Completion
2031-03-01

Drugs

EvaluationDrugModalityDoseRoute
Subject durvalumab-680LT Diagnostic / imaging agent 15 mg Intravenous
Subject durvalumab-680LT Diagnostic / imaging agent 25 mg Intravenous