Breast-milk Enema Administration to Stimulate Passage of Meconium

NCT07661992 ↗

Phase 1 Not yet recruiting 20 enrolled Wake Forest University Health Sciences

NaSingle-groupOpen-labelPrevention

Summary

Lack of passage of meconium in preterm infants delays feeding advancement and may represent a risk factor for necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP). Usual management of meconium impaction has included glycerin suppositories and normal saline enemas. Various methods are used in routine neonatal care to promote meconium evacuation; however, there is no consensus on the agents used and the frequency of applications

Timeline

Start: 2026-07
Primary completion: 2026-12
Completion: 2027-01

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Breast milk	Other / unclassified	5 unknown	Rectal

Indications

No indication recorded.