drugset / Trial / NCT07665814

Propolis-Based Solution Application in Extraction Socket Healing

NCT07665814 ↗

Phase 1/2 Completed 14 enrolled Saint-Joseph University
Non-randomizedCrossoverSingle-blindTreatment

Summary

This pilot study evaluated whether a propolis-based topical solution improves soft-tissue healing after tooth extraction. Thirteen patients requiring extraction of two comparable teeth on opposite sides of the mouth were enrolled in a split-mouth design, in which one extraction site received the propolis solution while the other served as an internal control. The test site was treated with the propolis solution three times daily for seven days, while the control site received only saline rinses. Healing was tracked using 3D intraoral scans obtained before extraction and on days 7 and 14 afterward, allowing the percentage of socket closure to be measured objectively over time. Postoperative pain was also assessed using a standard visual pain scale on days 1, 3, and 7. The study aimed to determine whether this propolis-based formulation could serve as a natural, low-cost adjunct to standard post-extraction care to support faster tissue repair.

Timeline

Start
2025-10-01
Primary completion
2026-04-01
Completion
2026-04-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Propolis-based topical solution Unknown — Topical

Indications

No indication recorded.