drugset / Trial / NCT07669675

TPO-RA Plus Baricitinib vs. TPO-RA for ITP

NCT07669675

Phase 2 Not yet recruiting 100 enrolled Peking University People's Hospital
RandomizedParallel-groupOpen-labelTreatment

Summary

This is a prospective, randomized, controlled trial. ITP patients who failed prior full-does TPO-RA monotheray for 14 days. Patients are randomly assigned at a 1:1 ratio to receive baricitinib plus TPO-RA or TPO-RA alone. Patients are randomly assigned at a 1:1 ratio to receive baricitinib plus TPO-RA or TPO-RA alone. The primary endpoint was the 14-day overall response rate without any rescue therapy.

Timeline

Start
2026-07-01
Primary completion
2027-12-31
Completion
2028-08-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Baricitinib Small molecule 2 mg Oral
Background Eltrombopag Small molecule 75 mg
Background Hetrombopag Small molecule 7.5 mg