drugset / Trial / NCT07669675
TPO-RA Plus Baricitinib vs. TPO-RA for ITP
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a prospective, randomized, controlled trial. ITP patients who failed prior full-does TPO-RA monotheray for 14 days. Patients are randomly assigned at a 1:1 ratio to receive baricitinib plus TPO-RA or TPO-RA alone. Patients are randomly assigned at a 1:1 ratio to receive baricitinib plus TPO-RA or TPO-RA alone. The primary endpoint was the 14-day overall response rate without any rescue therapy.
Timeline
- Start
- 2026-07-01
- Primary completion
- 2027-12-31
- Completion
- 2028-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Baricitinib | Small molecule | 2 mg | Oral |
| Background | Eltrombopag | Small molecule | 75 mg | — |
| Background | Hetrombopag | Small molecule | 7.5 mg | — |