drugset / Trial / NCT07673601

A Study to Assess the Absolute Bioavailability and How Adimanebart SC Moves Through the Body in Healthy Adult Participants

NCT07673601 ↗

Phase 1 Recruiting 52 enrolled argenx
RandomizedParallel-groupOpen-labelTreatment

Summary

This study aims to find out how much adimanebart gets into the blood circulation of healthy adults. Researchers will measure the amount of adimanebart in blood over time to learn how it moves through the body. The drug's safety will also be assessed. The participants will be assigned to one of 3 parts of the study: part 1 investigates the absolute bioavailability; part 2 investigates the effect of different body weights on adimanebart in blood after subcutaneous (SC) dosing; part 3 investigates formulation adaptations. Participants will be in the study for approximately up to 24 weeks.

Timeline

Start
2026-06-12
Primary completion
2026-12
Completion
2026-12

Drugs

EvaluationDrugModalityDoseRoute
Subject ARGX-119 Monoclonal antibody — Intravenous

Indications

No indication recorded.