Effects of Pregabalin Ultrasound Therapy and Nerve Exercises on Pain and Sensation in Diabetic Nerve Damage

Summary

Peripheral diabetic neuropathy (PDN) is a common complication of diabetes mellitus characterized by neuropathic pain, sensory disturbances, and impaired quality of life. This study aims to determine the effects of pregabalin phonophoresis combined with sural nerve flossing on neuropathic pain and sensory function in individuals with peripheral diabetic neuropathy. Participants will be randomly allocated to intervention groups and treated according to the study protocol. Outcomes related to neuropathic pain intensity and sensory function will be assessed before and after the intervention period to evaluate the effectiveness of the combined treatment approach.

Timeline

Start

2026-02-02

Primary completion

2026-04-30

Completion

2026-05-31

Publications

• Background Raj RRM, Saravanan T, Preethi P et al. (2022) Comparative evaluation of therapeutic ultrasound and phonophoresis in myofascial pain dysfunction syndrome. Journal of Indian Academy of Oral Medicine and Radiology 34(3): 242-245.
• Background Mahanta SK, Warikoo D, Rawat N et al. (2024) Effect of nerve flossing on nerve conduction velocity and pain in patients with diabetic neuropathy: An experimental study. Diabetes 19: 22.
• Background Bragg S, Marrison ST, Haley S. Diabetic Peripheral Neuropathy: Prevention and Treatment. Am Fam Physician. 2024 Mar;109(3):226-232.
• Background Ardeleanu V, Toma A, Pafili K, Papanas N, Motofei I, Diaconu CC, Rizzo M, Stoian AP. Current Pharmacological Treatment of Painful Diabetic Neuropathy: A Narrative Review. Medicina (Kaunas). 2020 Jan 9;56(1):25. doi: 10.3390/medicina56010025.
• Background Akhtar S, Hassan F, Saqlain SR, Ali A, Hussain S. The prevalence of peripheral neuropathy among the patients with diabetes in Pakistan: a systematic review and meta-analysis. Sci Rep. 2023 Jul 20;13(1):11744. doi: 10.1038/s41598-023-39037-1.
• Background Alsharidah AS (2024) Efficacy of gabapentin phonophoresis on post mastectomy intercostobrachial neuralgia. Fizjoterapia Polska 24(3): 1-9.

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