Enhancing Rehabilitation in Aging Study (ERAS)

Phase 1/2 Not yet recruiting 38 enrolled University of Florida

RandomizedCrossoverDouble-blindTreatment

Summary

Acute Intermittent Hypoxia (AIH) is a rehab approach attributed to serotonin. AIH signaling also occurs via adenosine, and the pathways inhibit each other. Increased neural adenosine in aging may stymie AIH plasticity. The hypothesis is pre-treatment with adenosine 2A receptor inhibition (A2AI) enhances AIH effects on motor plasticity in unaffected adults. AIH exposures will be paired with A2AI or placebo, with a 4-week washout. Primary outcome measures include inspiratory and grip strength.

Timeline

Start: 2026-10-01
Primary completion: 2031-05-31
Completion: 2031-12-31

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Istradefylline	Small molecule	20 mg	—

Indications

No indication recorded.