drugset
drugset / Trial / NCT07707778

Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV

NCT07707778 ↗

Phase 4 Enrolling by invitation 60 enrolled National Taiwan University Clinical Trial Center
Non-randomizedParallel-groupOpen-labelTreatment

Summary

This study is a pilot, open-lable, two-arm study. The investigators will enroll virally suppressed people living with HIV and obesity to evaluate the effect of tirzepatide on epigenetic aging, assessed by DNA methylation-based clocks using peripheral blood. In parallel, imaging studies will be performed to assess changes in body composition and intrahepatic fat content.

Timeline

Start
2026-06-25
Primary completion
2027-12
Completion
2027-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Tirzepatide Peptide — —

Indications

HIV infectious disease diabetes mellitus hyperlipidemia metabolic dysfunction-associated steatotic liver disease metabolic syndrome X obesity disorder