drugset / Trial / NCT07714200

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

NCT07714200

Not yet recruiting 120 enrolled VA Office of Research and Development
RandomizedParallel-groupOpen-labelTreatment

Summary

Seventy to eighty percent of Veterans experiencing homelessness (VEH) smoke, which is four times the rate of the U.S. population and 2.5 times higher than among impoverished Americans. Smoking- related deaths among persons experiencing homelessness occur at double the rate seen among more stably housed people. The purpose of this study study is to evaluate the effectiveness of an intervention to help Veterans experiencing homelessness stop smoking. The intervention, called Abstinence Reinforcement Therapy + (ART+), includes telehealth-based counseling, smoking cessation aids, and mobile contingency management (mCM). mCM is an intervention in which participants are paid for smoking abstinence. 120 Veterans who smoke cigarettes and are experiencing homelessness will be randomly assigned to receive either ART+ or usual smoking cessation care. The primary outcome to be evaluated is the rate at which Veterans assigned to the ART+ condition report smoking abstinence and have their abstinence verified using salivary testing.

Timeline

Start
2027-03-01
Primary completion
2030-03-01
Completion
2030-09-01

Drugs

EvaluationDrugModalityDoseRoute
Background Bupropion Small molecule 150 mg
Background Bupropion Small molecule 300 mg
Background Nicotine Unknown
Background Varenicline Small molecule 0.5 mg
Background Varenicline Small molecule 2 mg

Indications