drugset / Trial / NCT07743671

A Trial to Assess the Efficacy and Safety of Engasertib in Participants With Moderate to Severe Hereditary Hemorrhagic Telangiectasia (HHT)

NCT07743671 ↗

Phase 3 Recruiting 240 enrolled Vaderis Therapeutics AG
RandomizedParallel-groupDouble-blindTreatment

Summary

The primary objective of this trial is to assess the efficacy of engasertib 40 mg once daily (QD) in reducing the frequency of epistaxis compared to placebo QD during 28 weeks of double-blind treatment in participants with moderate to severe HHT.

Timeline

Start
2026-09
Primary completion
2028-06
Completion
2028-06

Drugs

EvaluationDrugModalityDoseRoute
Subject VAD044 Small molecule 40 mg Oral