Eplerenone and IOP in Healthy Adults

Summary

The goal of this clinical trial is to determine whether eplerenone lowers eye pressure in healthy adults. Eplerenone is a medication approved by the U.S. Food and Drug Administration for other medical conditions. Researchers will compare eplerenone with placebo (a substance containing no active drug) to determine whether eplerenone affects intraocular pressure (IOP). Participants will receive both eplerenone and placebo during different study periods and will have their eye pressure measured throughout the study. Blood pressure, kidney function, and potassium levels will also be monitored for safety.

Timeline

Start

2026-10-01

Primary completion

2027-02-01

Completion

2027-04-01

Publications

• Background Razavi SMS, Daneshvar R. Possible dose-dependent effect of eplerenone on intraocular pressure. Indian J Ophthalmol. 2023 Oct;71(10):3357-3360. doi: 10.4103/IJO.IJO_175_23.

Drugs

Indications