drugset / Trial / NCT07805837
Comparative Immunologic Mechanisms and Microbiome Interactions Following Different Influenza Vaccine Formulations in Older Adults
RandomizedParallel-groupOpen-labelPrevention
Summary
This prospective, randomized, open-label clinical study aims to evaluate the immunogenicity and underlying immune mechanisms of different influenza vaccine formulations in adults aged ≥65 years. Additionally, the study investigates the role of the gut microbiome in modulating vaccine-induced immune responses and durability.
Timeline
- Start
- 2025-10-25
- Primary completion
- 2026-01-31
- Completion
- 2026-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Efluelda | Vaccine | 0.7 ml | Intramuscular |
| Comparator | Fluad | Vaccine | 0.5 ml | Intramuscular |
| Comparator | Vaxigrip | Vaccine | 0.5 ml | Intramuscular |