drugset / Trial / NCT07808138
RADICAL-IO: thRee Cycles of immunotherApy Without raDical Therapy In mediCALly InOperable Stage I Non-small Cell Lung Cancer
Phase 2
Not yet recruiting
30 enrolled
The Netherlands Cancer Institute
Leiden University Medical Center · collabRegeneron Pharmaceuticals · collab
NaSingle-groupOpen-labelTreatment
Summary
Traditionally, chemotherapy and/or immunotherapy are combined with surgery or radiotherapy to cure patients with lung cancer. However, some patients treated with immunotherapy appear to be cured before surgery or radiotherapy. In this study, patients with a high chance to respond to immunotherapy will be selected. These patients will be treated with immunotherapy alone, thereby evaluating whether these patients can be cured without surgery or radiotherapy.
Timeline
- Start
- 2026-11
- Primary completion
- 2029-12-01
- Completion
- 2029-12-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Cemiplimab | Monoclonal antibody | 350 mg | Intravenous |