drugset / Trial / NCT07810101
Evaluation of the Efficacy of Topical Application of Liquid Nitrogen and Ascorbic Acid in Treatment of Gingival Pigmentation
RandomizedParallel-groupOpen-labelTreatment
Summary
Aim of study The present study will be designed to evaluate the clinical and histomorphometric outcomes of using topical liquid nitrogen and topical ascorbic acid in gingival depigmentation. Primary outcome: • Clinical severity and extension of gingival pigmentation. Secondary outcome: • Histologic assessment of the melanin forming cells.
Timeline
- Start
- 2026-09-01
- Primary completion
- 2027-02-01
- Completion
- 2027-04
Publications
- Background Kamboj S, Salaria SK. Efficacy of liquid nitrogen and electrocautery assisted gingival depigmentation in term of patient's perception, histological wound healing - A randomized triple blind clinical trial. J Indian Soc Periodontol. 2020 Mar-Apr;24(2):135-144. doi: 10.4103/jisp.jisp_438_19. Epub 2020 Mar 2.
- Background El-Mofty M, Elkot S, Ghoneim A, Yossri D, Ezzatt OM. Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study. Clin Oral Investig. 2021 Dec;25(12):6881-6889. doi: 10.1007/s00784-021-03978-6. Epub 2021 May 8.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Liquid nitrogen | Other / unclassified | — | Topical |
| Comparator | Vitamin C | Other / unclassified | — | Topical |