Standard Versus Double Alpha Blockers Treatment for Symptomatic Benign Prostatic Obstruction

Summary

Failed medical treatment to alleviate LUTS and AUR is an indication for intervention, some trials were published elucidating the possible use of standard dose tamsulosin and silodosin and double dose tamsulosin but to the best of our knowledge, no studies with head-to-head comparison between Tamsulosin and Combination of Tamsulosin and Silodosin for Management of Lower Urinary Tract Symptoms and Acute Urine Retention in Patients with Benign Prostatic Hyperplasia.

Timeline

Start

2025-10-12

Primary completion

2026-10

Completion

2026-11

Publications

• Background Osman T, Elawady H, Fawaz K, Shabayek M, Essam MD, Osman D, ElSaeed KO. Evaluation of Tamsulosin 0.4 mg versus 0.8 mg in management of lower urinary tract symptoms due to benign prostatic enlargement. Int Urol Nephrol. 2024 Jun;56(6):1811-1816. doi: 10.1007/s11255-023-03912-7. Epub 2024 Jan 14.

Drugs

Indications