drugset / Trial / NCT07851246

A Study to Evaluate the Immune Response and Safety of a Vaccine Against Influenza in Adults 18-64 Years of Age

NCT07851246 ↗

Phase 3 Recruiting 3000 enrolled GlaxoSmithKline
RandomizedParallel-groupTriple-blindPrevention

Summary

This clinical trial will study an investigational seasonal influenza vaccine in adults 18 to 64 years of age. The vaccine is based on messenger ribonucleic acid, also called mRNA. The main goals of the study are to learn how well the vaccine helps the body make an immune response against influenza and what medical problems participants may have after vaccination. Researchers will also compare immune responses in adults 18 to 64 years of age from this study, with immune responses in adults 65 years of age and older from another study. Participants will receive 1 injection into the upper arm muscle and will be followed for about 6 months.

Timeline

Start
2026-10-01
Primary completion
2027-07-09
Completion
2027-07-09

Drugs

EvaluationDrugModalityDoseRoute
Comparator Comparator 1 Vaccine — Intramuscular
Comparator Comparator 2 Vaccine — Intramuscular
Subject mRNA Seasonal Flu vaccine Messenger RNA (mRNA) — Intramuscular

Indications