Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia

Summary

This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery. Participants will receive either 20 mg of furosemide or a placebo tablet once daily for 5 days, in addition to standard postpartum treatment for high blood pressure. Blood pressure, symptoms, adverse events, and the need for additional antihypertensive medication will be monitored for 7 days after delivery. The study will assess whether adding furosemide helps achieve better postpartum blood pressure control compared with placebo.

Timeline

Start

2026-10-01

Primary completion

2027-03-15

Completion

2027-05-25

Publications

• Background Pagan M, Ounprpaseuth ST, Ghahremani T, Doiron T, Magann EF. Furosemide for postpartum blood pressure control in patients with hypertensive disorders. Eur J Obstet Gynecol Reprod Biol X. 2023 May 3;18:100195. doi: 10.1016/j.eurox.2023.100195. eCollection 2023 Jun.
• Background Lopes Perdigao J, Lewey J, Hirshberg A, Koelper N, Srinivas SK, Elovitz MA, Levine LD. Furosemide for Accelerated Recovery of Blood Pressure Postpartum in women with a hypertensive disorder of pregnancy: A Randomized Controlled Trial. Hypertension. 2021 May 5;77(5):1517-1524. doi: 10.1161/HYPERTENSIONAHA.120.16133. Epub 2021 Feb 8.
• Background Hup RJ, Paauw ND, Lely AT, Depmann M. Oral antihypertensive agents and diuretics in the management of hypertension in postpartum women: a systematic review and meta-analysis. BMJ Open. 2024 Dec 20;14(12):e086208. doi: 10.1136/bmjopen-2024-086208.
• Background Veena P, Perivela L, Raghavan SS. Furosemide in postpartum management of severe preeclampsia: A randomized controlled trial. Hypertens Pregnancy. 2017 Feb;36(1):84-89. doi: 10.1080/10641955.2016.1239735. Epub 2016 Nov 11.
• Background Steele DW, Adam GP, Saldanha IJ, Kanaan G, Zahradnik ML, Danilack VA, Stuebe AM, Peahl AF, Chen KK, Balk EM. Management of Postpartum Hypertensive Disorders of Pregnancy [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2023 May. Report No.: AHRQ 23-EHC012Report No.: PCORI(R) 2023-SR-02. Available from http://www.ncbi.nlm.nih.gov/books/NBK592560/
• Background Keiseb J, Moodley J, Connolly CA. Comparison of the efficacy of continuous furosemide and low-dose dopamine infusion in preeclampsia/eclampsia-related oliguria in the immediate postpartum period. Hypertens Pregnancy. 2002;21(3):225-34. doi: 10.1081/PRG-120016787.

Drugs

Indications