Drugs / Permethrin
Permethrin
also known as
Nix Crème Rinse · Activyl tick plus · Elimite · InfectoScab 5% Cream · Lyclear · Lythrin · Nix Creme Rinse Lice Treatment · NSC-760105 · +5 more
Regulatory milestones approvals, filings & regulatory actions · 3 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | NIX | — | 1996-11-01 | fda.gov ↗ |
| Label expansion | US (FDA) | ELIMITE | — | 1993-05-05 | fda.gov ↗ |
| Approved | US (FDA) | NIX | — | 1986-03-31 | fda.gov ↗ |
Trials 11
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 23 trials | ||||||
| Phase 2 | NCT06896929 | May 2025 → Apr 2026 overdue | scabies | Children Hospital and Institute of Child Health, Lahore | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT02094716 | Apr → Dec 2014 | scabies | Mylan Inc. | Completed | No outcome recorded |
| Phase 2 | NCT00262418 | Jul 2004 → May 2005 | scabies | University Ghent | Completed | No outcome recorded |
| Phase 36 trials · 1 missed | ||||||
| Phase 3 | NCT06396507 | Mar → Sep 2022 | scabies | Damascus University | Completed | No outcome recorded |
| Phase 3 | NCT04814511 | Jun 2021 → Dec 2022 | scabies | Infectopharm Arzneimittel GmbH | Unknown | No outcome recorded |
| Phase 3 | NCT03178942 | Jun → Nov 2017 | scabies | Encube Ethicals Pvt. Ltd. | Completed | No outcome recorded |
| Phase 3 | NCT02978508 | Nov 2016 → May 2017 | scabies | Mayne Pharma International Pty Ltd | Completed | No outcome recorded |
| Phase 3 | NCT02407782 | Jan 2016 → Dec 2021 | scabies | University Hospital, Bordeaux | Completed | Missed primary |
| Phase 3 | NCT02572986 | Sep 2015 → Jun 2016 | scabies | Dr. Reddy's Laboratories Limited | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT01287663 | Jan 2011 → May 2012 | Pediculus humanus corporis infestation | Assistance Publique Hopitaux De Marseille | Terminated | No outcome recorded |
| — | NCT00604084 | May 2007 → May 2008 | scabies | Edward Via Virginia College of Osteopathic Medicine | Completed | No outcome recorded |
| Comparator or background therapy26 trials | ||||||
| Phase 0 | NCT07247630 Comparator | Jan → Mar 2026 overdue | scabies | College of Physicians and Surgeons Pakistan | Not yet recruiting | No outcome recorded |
| Phase 1 | NCT05862701 Comparator | Mar → Sep 2022 | scabies | Combined Military Hospital Abbottabad | Completed | No outcome recorded |
| Phase 1 | NCT05643820 Comparator | Mar → Aug 2022 | lice infestation | Combined Military Hospital Abbottabad | Completed | No outcome recorded |
| Phase 1 | NCT05362513 Comparator | Jun → Nov 2021 | scabies | Combined Military Hospital Abbottabad | Completed | No outcome recorded |
| Phase 2 | NCT04332068 Comparator | Nov 2023 → Apr 2025 | scabies | University of Oxford | Completed | No outcome recorded |
| Phase 2 | NCT02213055 Comparator | May 2009 → Aug 2014 | Pediculus humanus capitis infestation | Hackensack Meridian Health | Completed | No outcome recorded |
| Phase 2 | NCT00857935 Comparator | Mar → Apr 2007 | Pediculus humanus capitis infestation | ParaPRO LLC | Completed | No outcome recorded |
| Phase 3 | NCT07159373 Background | Sep 2026 → Jun 2027 expected | filariasis, scabies, strongyloidiasis | Medicines Development for Global Health | Recruiting | No outcome recorded |
| Phase 3 | NCT06380452 Comparator | May 2024 → Jul 2027 expected | scabies | Infectopharm Arzneimittel GmbH | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT03236168 Background | Aug → Dec 2017 | Pediculus humanus capitis infestation, scabies | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 3 | NCT00963508 Comparator | Aug 2009 → Mar 2010 | lice infestation | Sun Pharmaceutical Industries, Inc. | Completed | Met primary |
| Phase 3 | NCT00927472 Comparator | Aug 2009 → May 2010 | Pediculus humanus capitis infestation | Sun Pharmaceutical Industries, Inc. | Completed | Met primary |
| Phase 3 | NCT00545753 Comparator | Sep 2007 → Mar 2008 | lice infestation | ParaPRO LLC | Completed | No outcome recorded |
| Phase 3 | NCT00545168 Comparator | Sep 2007 → Mar 2008 | Pediculus humanus capitis infestation | ParaPRO LLC | Completed | No outcome recorded |
| Phase 3 | NCT00244439 Comparator | Dec 2005 → Oct 2006 | Pediculus humanus capitis infestation | Sun Pharmaceutical Industries, Inc. | Completed | No outcome recorded |
| Phase 3 | NCT02500524 Comparator | Jul 1998 → Jan 1999 | Pediculus humanus capitis infestation | Medical Entomology Centre | Terminated | No outcome recorded |
| Phase 4 | NCT07822672 Comparator | Jun 2024 → May 2026 | scabies | Can Tho University of Medicine and Pharmacy | Completed | No outcome recorded |
| Phase 4 | NCT05819983 Comparator | Jan → Feb 2023 | scabies | Padjadjaran University | Completed | No outcome recorded |
| Phase 4 | NCT05565820 Comparator | Dec 2022 → Mar 2023 | Pediculus humanus capitis infestation | Alliance Pharmaceuticals | Completed | No outcome recorded |
| Phase 4 | NCT03105505 Comparator | Apr 2017 → Sep 2018 | blepharitis | Barzilai Medical Center | Unknown | No outcome recorded |
| Phase 4 | NCT02775617 Background | Jul 2016 → Aug 2017 | impetigo, scabies, yaws | London School of Hygiene and Tropical Medicine | Completed | No outcome recorded |
| Phase 4 | NCT02653898 Comparator | Jan → Aug 2016 | malaria | Armed Forces Research Institute of Medical Sciences, Thailand | Unknown | No outcome recorded |
| — | NCT05378477 Comparator | Jan → Sep 2022 | Pediculus humanus capitis infestation | Oystershell NV | Unknown | No outcome recorded |
| — | NCT03177993 Background | Jul → Nov 2017 | Nematoda infectious disease, filariasis, impetigo, scabies | Washington University School of Medicine | Completed | No outcome recorded |
| — | NCT05198947 Comparator | Jan → Dec 2017 | scabies | B.P. Koirala Institute of Health Sciences | Completed | No outcome recorded |
| — | NCT01514513 Comparator | Aug → Nov 2011 | Pediculus humanus capitis infestation | South Florida Family Health and Research Centers | Completed | No outcome recorded |
News releases announcing trial results or a regulatory action · 1
| Date | Issuer | Release |
|---|---|---|
| 2015-12-10 | Medicines Development for Global Health | Results Mass drug administration for scabies control medicinesdevelopment.com ↗
The elegantly conducted randomised study, undertaken in Fijian island communities, demonstrated that oral ivermectin MDA was superior to permethrin cream MDA in reducing the prevalence of scabies infection. |
All press releases naming this drug 1 release
| Date | Issuer | Release |
|---|---|---|
| 2015-12-10 | Medicines Development for Global Health | Mass drug administration for scabies control medicinesdevelopment.com ↗ |
Evidence & citations 17 cited values
Every value below carries the sentence it was read from. 39 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Permethrin | “InfectoScab 5 % Creme is the already approved standard therapeutic agent, containing the active ingredient permethrin in 5 % concentration.” NCT04814511 ↗36“The most common treatments are pesticide-based, over-the-counter remedies of permethrin (1%), or pyrethrin-based products.” NCT02213055 ↗ “Participants excluded from ivermectin will receive a topical dose of permethrin cream.” NCT03177993 ↗ “Conventional pesticide, containing 1% permethrin.” NCT05378477 ↗ “1% permethrin lotion for topical application.” NCT05565820 ↗ “Permethrin 5% lotion” NCT00604084 ↗ “permethrin 5% cream” NCT07159373 ↗ |
| Known as | Activyl tick plus | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Known as | Elimite | “This study will evaluate the therapeutic equivalence of a generic permethrin cream 5% to Elimite® in the Treatment of Scabies.” NCT02572986 ↗ |
| Known as | InfectoScab 5% Cream | “The multi-center, prospective, randomized, double-blind phase III clinical trial will primarily investigate the efficacy and safety of treatment of scabies with Permethrin...” NCT06380452 ↗ |
| Known as | Lyclear | “Lyclear (Permethrin 5%)” NCT03105505 ↗ |
| Known as | Lythrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Known as | Nix Creme Rinse Lice Treatment | “Staff will shake Nix Creme Rinse Lice Treatment (1% permethrin lotion) well before applying” NCT05565820 ↗ |
| Known as | Nix Crème Rinse | “Nix Crème Rinse (1% permethrin) used as labeled, for the treatment of head lice.” PMID 17845167 ↗ Jul 20071“NIX Creme Rinse - 1% permethrin” NCT00857935 ↗ |
| Known as | NSC-760105 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Known as | Permethrin component of activyl tick plus | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Known as | Permethrin component of vectra 3d | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Known as | Permethrin Cream, 5% | “Permethrin Cream, 5%” NCT02978508 ↗ |
| Known as | Permethrine | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Known as | Permetrina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1525 ↗ |
| Action | Inhibit | “Permethrin acts by disrupting the sodium channel current, resulting in delayed repolarization, paralysis, and death of the parasite.” NCT05819983 ↗ |
| Modality | Small molecule | “It is a synthetic pyrethroid that is safe for use in adults and children 2 months and older.” NCT02572986 ↗ |
| Route | Topical | “Topical application for 10 minutes, followed by a complete rinse off, followed by a nit combing regimen” NCT00545168 ↗ |