Oral Ivermectin Versus Topical Permethrin to Treat Scabies in Children and Adults

Summary

Scabies remains a frequent condition that affects adults and children. The aim of this study is to compare the efficacy and safety of two drug treatments against scabies in children and their close contacts. One group will apply topical permethrin 5% and the other group will receive oral ivermectin. Both groups will be treated twice, once at inclusion and the second time 10 days later. Both treatment regimens have been used widely and are safe to use.

Timeline

Start

2016-01-19

Primary completion

2021-12-16

Completion

2022-01-18

Outcome

Missed primary endpoint

paper did not show the non-inferiority of oral ivermectin compared with 5% permethrin cream PMID 41494769 ↗

Publications

• Boralevi F, Simon G, Bernigaud C, Brun J, Goujon E, Perrot JL, Phan A, Herisse AL, Maruani A, Vanhaecke C, Couty E, Abasq-Thomas C, Fournet M, Mallet S, Brenaut E, Hubiche T, Balguerie X, Caux F, Beneton N, Dutkiewicz AS, Adamski H, Aubert H, Bourrat E, Couzan C, Eyraud A, Janela-Lapert R, Marti A, Miquel J, Richard M, Barbarot S, Bonniaud B, Chabbert C, Delion F, Dinulescu M, Duong TA, Etienne M, Hirsch G, Isnard C, Huet F, Le Bidre E, Leducq S, Legrand A, Monestier S, Morice-Picard F, Seneschal J, Capelli A, Lacoste C, Labreze C, Miraglia G, Do-Pham G, Giraudeau B, Chosidow O. Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicentre, assessor blinded, cluster randomised clinical trial. BMJ. 2026 Jan 6;392:e086277. doi: 10.1136/bmj-2025-086277.

Drugs

Indications