Drugs / OTENABANT
last change Oct 2014 re-read 2 minutes ago

OTENABANT

Small molecule targets CNR1 via inhibition

Developed for
obesity disorder · metabolic dysfunction-associated steatohepatitis
Investigated by
Pfizer · National Institute on Aging (NIA)

Trials 11 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 17 trials
Phase 1 NCT01517100 Jan 2012 → Oct 2014 National Institute on Aging (NIA) Completed No outcome recorded
Phase 1 NCT00706537 Jul → Nov 2008 metabolic dysfunction-associated steatohepatitis Pfizer Completed No outcome recorded
Phase 1 NCT00645021 Apr → Oct 2008 liver disorder, obesity disorder Pfizer Completed No outcome recorded
Phase 1 NCT00644839 Apr → Jul 2008 obesity disorder Pfizer Completed No outcome recorded
Phase 1 NCT00472836 Jun 2007 → Oct 2008 obesity disorder Pfizer Completed No outcome recorded
Phase 1 NCT00645216 Jun → Oct 2007 obesity disorder Pfizer Completed No outcome recorded
Phase 1 NCT00645463 Mar → Jun 2007 obesity disorder Pfizer Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT00134199 Mar → Nov 2005 obesity disorder Pfizer Completed No outcome recorded
Phase 33 trials
Phase 3 NCT00396448 Feb 2007 → Feb 2009 obesity disorder Pfizer Terminated No outcome recorded
Phase 3 NCT00391196 Nov 2006 → Dec 2008 obesity disorder Pfizer Terminated No outcome recorded
Phase 3 NCT00375401 Oct 2006 → Jan 2009 obesity disorder Pfizer Terminated No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 3 NCT00483171 Comparator Jan 2008 → Jan 2009 obesity disorder Pfizer Terminated No outcome recorded

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 13 sources stand behind the page.

FieldValueCited text
Known as OTENABANT ChEMBL registry synonym — accepted as the source's own label CHEMBL562668
Known as CP-945,598 “CP-945598 is a potent and selective Cannabinoid-1 (CB1) receptor antagonist currently being developed for the treatment of obesity.” NCT00706537
11

NCT01517100

NCT00396448

NCT00391196

NCT00134199

NCT00472836

NCT00375401

NCT00645216

NCT00645021

NCT00644839

NCT00483171

NCT00645463

Known as CP-945598-01 ChEMBL registry synonym — accepted as the source's own label CHEMBL562668
Known as Otenabant hcl ChEMBL registry synonym — accepted as the source's own label CHEMBL562668
Known as OTENABANT HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL562668
Action Inhibit “Cannabinoid-1 (CB1) receptor antagonist” NCT00706537
1

“Cannabinoid CB1 receptor antagonist” CHEMBL562668

Modality Small molecule CHEMBL562668
Route Oral “multiple oral dose administration” NCT00706537
Target CNR1 “Cannabinoid CB1 receptor antagonist” CHEMBL562668