Sulfamethoxazole-Trimethoprim

also known as SMX/TMP · co-trimoxazole · Septra · TMP-SMX · Trimethoprim/Sulfamethoxazole

Developed for: HIV infectious disease · pneumocystosis · measles · chronic otitis media
Investigated by: National Institute of Allergy and Infectious Diseases (NIAID) · Glaxo Wellcome · Bandim Health Project · Medical Research Council Unit, The Gambia · Rigshospitalet, Denmark

Trials 7

today NCT06709196 · Ph 4 NCT00000826 · Ph 1 NCT00168532 · Ph 3 NCT00000816 · Ph 4 NCT00000991 · Ph 3 NCT00000655 · Ph 2 NCT00000730 · Ph 3

1989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 11 trial
Phase 1	NCT00000826	? → May 1999	HIV infectious disease, bacterial infectious disease, fungal infectious disease	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 21 trial
Phase 2	NCT00000655	? → Jan 1992	HIV infectious disease, pneumocystosis	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 33 trials
Phase 3	NCT00168532	Jan 1998 → Oct 2001	measles	Bandim Health Project	Completed	Mixed
Phase 3	NCT00000730	? → Mar 1989	HIV infectious disease, pneumocystosis	National Institute of Allergy and Infectious Diseases (NIAID)	Terminated	No outcome recorded
Phase 3	NCT00000991	? → Apr 1994	HIV infectious disease, pneumocystosis	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Phase 42 trials
Phase 4	NCT06709196	Jan 2025 → Jan 2027 expected	urinary bladder cancer	Rigshospitalet, Denmark	Recruiting	No outcome recorded
Phase 4	NCT00000816	? → Sep 1996	HIV infectious disease, pneumocystosis	National Institute of Allergy and Infectious Diseases (NIAID)	Completed	No outcome recorded
Comparator or background therapy2 trials
Phase 3	NCT05384197 Comparator	May 2022 → May 2023	nephrolithiasis	Mansoura University	Unknown	No outcome recorded
—	NCT00189098 Comparator	Feb 2003 → Jun 2006	chronic otitis media	UMC Utrecht	Completed	No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 12 sources stand behind the page.

Field	Value	Cited text
Known as	Sulfamethoxazole/Trimethoprim	“To determine whether gradual initiation of sulfamethoxazole/trimethoprim (SMX/TMP) reduces the incidence of treatment-limiting adverse reactions compared to the routine...” NCT00000816 ↗ 12 “Both sulfamethoxazole/trimethoprim (SMX/TMP) and dapsone probably also provide effective preventive treatment against PCP, and both may be useful in preventing toxoplasmosis...” NCT00000991 ↗ “A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients” NCT00000655 ↗ “Sulfamethoxazole-Trimethoprim (TMP-SMX) twice daily will be utilized as the first choice AP for 2 days” NCT05384197 ↗ “sulfamethoxazole/trimethoprim (SMX/TMP)” NCT00000730 ↗ NCT00000730 ↗ NCT00168532 ↗ NCT00000826 ↗ NCT00000655 ↗ NCT00000816 ↗ NCT00000991 ↗ Show 2 more sources
Known as	co-trimoxazole	“subjects received cotrimoxazole (1 tablet of 800 mg sulfamethoxazole/160 mg trimethoprim daily) alone for 2 weeks” PMID 15470330 ↗ Oct 2004 1 “INTERVENTIONS: Sulfamethoxazole-trimethoprim (co-trimoxazole) or placebo for seven days.” PMID 17060336 ↗ Oct 2006
Known as	Septra	“A Randomized, Double-Blind Study of 566C80 Versus Septra (Trimethoprim/Sulfamethoxazole) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients” NCT00000655 ↗
Known as	SMX/TMP	“To determine whether gradual initiation of sulfamethoxazole/trimethoprim (SMX/TMP) reduces the incidence of treatment-limiting adverse reactions compared to the routine...” NCT00000816 ↗ 3 “Both sulfamethoxazole/trimethoprim (SMX/TMP) and dapsone probably also provide effective preventive treatment against PCP, and both may be useful in preventing toxoplasmosis...” NCT00000991 ↗ “In Part A, patients receive sulfamethoxazole-trimethoprim (SMX/TMP) alone for 2 weeks, then in combination with fluconazole, rifabutin, or both drugs, each over 2-week periods...” NCT00000826 ↗ “sulfamethoxazole/trimethoprim (SMX/TMP)” NCT00000730 ↗
Known as	TMP-SMX	“Sulfamethoxazole-Trimethoprim (TMP-SMX) twice daily will be utilized as the first choice AP for 2 days” NCT05384197 ↗
Known as	Trimethoprim/Sulfamethoxazole	“A Randomized, Double-Blind Study of 566C80 Versus Septra (Trimethoprim/Sulfamethoxazole) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients” NCT00000655 ↗
Route	Oral	“6 to 12 weeks of orally administered trimethoprim/sulfamethoxazole (18 mg/kg, 2 times per day)” PMID 17473089 ↗ May 2007