Drugs / Necitumumab

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Portrazza 2016-02-15 europa.eu
Approved US (FDA) PORTRAZZA 2015-11-24 fda.gov

Trials 23 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT03360734 Nov 2017 → May 2020 cancer Glycotope GmbH Completed No outcome recorded
Phase 1 NCT03054038 Jul 2017 → Mar 2022 non-small cell lung carcinoma Vanderbilt-Ingram Cancer Center Terminated No outcome recorded
Phase 1 NCT02789345 Oct 2016 → Oct 2017 non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT02496663 May 2016 → Jun 2027 expected non-small cell lung carcinoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1 NCT02451930 Sep 2015 → Jan 2017 non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT02411591 Jun 2015 → Jun 2017 metastatic neoplasm, non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT01088464 Jan 2010 → Feb 2012 neoplasm Eli Lilly and Company Completed No outcome recorded
Phase 1 NCT00801177 Nov 2004 → Feb 2007 cancer Eli Lilly and Company Completed No outcome recorded
Phase 1/23 trials
Phase 1/2 NCT04285671 Jan 2021 → Dec 2026 expected non-small cell lung carcinoma Jonsson Comprehensive Cancer Center Active not recruiting No outcome recorded
Phase 1/2 NCT03387111 Jan 2018 → Apr 2019 squamous cell carcinoma ImmunityBio, Inc. Terminated No outcome recorded
Phase 1/2 NCT01763788 May 2013 → Jun 2017 non-small cell squamous lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 210 trials
Phase 2 NCT03944772 Jun 2019 → May 2025 overdue non-small cell lung carcinoma AstraZeneca Active not recruiting No outcome recorded
Phase 2 NCT03574818 May → Oct 2018 squamous cell lung carcinoma Montefiore Medical Center Terminated No outcome recorded
Phase 2 NCT02941601 Nov 2016 → Dec 2017 non-small cell squamous lung carcinoma Eli Lilly and Company Withdrawn No outcome recorded
Phase 2 NCT02392507 Oct 2015 → Jan 2018 non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT02443337 Jul 2015 → Sep 2017 non-small cell lung carcinoma Eli Lilly and Company Terminated No outcome recorded
Phase 2 NCT01788566 Mar 2013 → Aug 2014 non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT01769391 Jan 2013 → Apr 2015 non-small cell squamous lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT01624467 Aug 2012 → May 2014 cancer Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT01606748 Aug 2012 → Jun 2013 cancer Eli Lilly and Company Completed No outcome recorded
Phase 2 NCT00835185 Aug 2007 → Jan 2010 colorectal cancer Eli Lilly and Company Completed No outcome recorded
Phase 32 trials
Phase 3 NCT00981058 Jan 2010 → Jun 2013 non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT00982111 Nov 2009 → Nov 2012 non-small cell lung carcinoma Eli Lilly and Company Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 25 sources stand behind the page.

FieldValueCited text
Known as Necitumumab ClinicalTrials.gov intervention name — accepted as the source's own label NCT00981058
19

NCT04285671

NCT02443337

NCT02789345

NCT03944772

NCT01624467

NCT02451930

NCT02941601

NCT01763788

NCT01788566

NCT01606748

NCT01769391

NCT03574818

NCT03360734

NCT00982111

NCT02392507

NCT03054038

NCT02496663

NCT03387111

NCT02411591

Known as 11F8 ChEMBL registry synonym — accepted as the source's own label CHEMBL1743047
Known as IMC-11F8 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01088464
2

NCT00801177

NCT00835185

Known as Portrazza ChEMBL registry synonym — accepted as the source's own label CHEMBL1743047
Action Inhibit “competitively inhibits ligand binding” PMID 25701171 Feb 2015
Modality Monoclonal antibody “fully human anti-EGFR monoclonal antibodyNCT00801177
Route Intravenous “Cycle of therapy administered intravenously, once a week for 6 weeks, for a total of six doses per cycle.” NCT00801177
Target EGFR “anti-EGFRNCT00801177