drugset / Trial / NCT02451930

A Study of the Combination of Necitumumab (LY3012211) and Pembrolizumab (MK3475) in Participants With NSCLC

NCT02451930 ↗

NaSequentialOpen-labelTreatment

Summary

The main purpose of this study is to evaluate the safety and efficacy of the combination of necitumumab with pembrolizumab in participants with stage IV non-small cell lung cancer (NSCLC).

Timeline

Start
2015-09-04
Primary completion
2017-01-26
Completion
2019-09-17

Outcome

Missed primary endpoint

registry analysis (other test); Part A Cohort 1: 600 mg Neci + 200 mg Pembro vs Part A Cohort 2, Part B: 800 mg Neci + 200 mg Pembro; p = 0.4491; Fisher Exact NCT02451930 ↗

Drugs

EvaluationDrugModalityDoseRoute
Subject Necitumumab Monoclonal antibody 600 mg Intravenous
Subject Necitumumab Monoclonal antibody 800 mg Intravenous
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous