Drugs / VARICELLA ZOSTER VIRUS ENVELOPE GLYCOPROTEIN E
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VARICELLA ZOSTER VIRUS ENVELOPE GLYCOPROTEIN E

Vaccine

Developed for
herpes zoster · varicella zoster infection · B-cell chronic lymphocytic leukemia · cardiovascular disorder · chronic lymphocytic leukemia/small lymphocytic lymphoma · COVID-19 · dementia · rheumatic disorder
+3 more · rheumatoid arthritis · type 1 diabetes mellitus · Waldenstrom macroglobulinemia
Investigated by
GlaxoSmithKline · National Heart, Lung, and Blood Institute (NHLBI) · National Institute of Allergy and Infectious Diseases (NIAID) · Seoul National University Hospital · University of Colorado, Denver · Abogen Biosciences (Shanghai) Co., Ltd
+39 more · Ann & Robert H Lurie Children's Hospital of Chicago · Boston Medical Center · Bristol-Myers Squibb · Calmy Alexandra · Central Adelaide Local Health Network Incorporated · Children's Hospital Colorado · Children's Hospital Medical Center, Cincinnati · Deepali Kumar · Dr Arto Palmu · Dynavax Technologies Corporation · Emory University · EyeGene Inc. · Finnish Vaccine Research; · Guangzhou Patronus Biotech Co., Ltd. · Janssen Research & Development, LLC · Kevin Winthrop · Loyola University · Ministry of Health, Saudi Arabia · National Health and Medical Research Council, Australia · National Institute on Aging (NIA) · National Medical Center, Seoul · Novotech (Australia) Pty Limited · Oklahoma Medical Research Foundation · Oriol Manuel · Prof Patrice Lalive · Radboud University Medical Center · Region Skane · RenJi Hospital · Royal Prince Alfred Hospital, Sydney, Australia · SMG-SNU Boramae Medical Center · Suzhou Abogen Biosciences Co., Ltd. · Tor Biering-Sørensen · University Health Network, Toronto · University of Adelaide · University of Alabama at Birmingham · University of Oklahoma · University of Rochester · University of Sao Paulo General Hospital · University of Washington

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Shingrix 2018-03-21 europa.eu

Trials 60 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 03 trials
Phase 0 NCT04523246 Sep 2020 → Dec 2021 COVID-19, herpes zoster University of Oklahoma Completed No outcome recorded
Phase 0 NCT03953196 Apr → Dec 2019 Janssen Research & Development, LLC Completed No outcome recorded
Phase 0 NCT03771157 Feb 2019 → Sep 2020 B-cell chronic lymphocytic leukemia, Waldenstrom macroglobulinemia University of Rochester Completed No outcome recorded
Phase 13 trials
Phase 1 NCT07285265 May → Nov 2025 overdue varicella zoster infection Suzhou Abogen Biosciences Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT04210752 Feb → Dec 2020 herpes zoster EyeGene Inc. Completed No outcome recorded
Phase 1 NCT01086449 Mar → Jun 2010 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT06569823 Jun 2024 → Nov 2027 expected herpes zoster Dynavax Technologies Corporation Active not recruiting No outcome recorded
Phase 1/2 NCT05580458 Mar 2023 → Feb 2027 expected herpes zoster National Institute of Allergy and Infectious Diseases (NIAID) Recruiting No outcome recorded
Phase 213 trials
Phase 2 NCT07614412 Jan 2027 → Jan 2028 expected type 1 diabetes mellitus Ministry of Health, Saudi Arabia Not yet recruiting No outcome recorded
Phase 2 NCT07443709 Apr → Dec 2026 expected herpes zoster Oriol Manuel Not yet recruiting No outcome recorded
Phase 2 NCT07311148 Oct 2025 → Jan 2026 overdue herpes zoster Guangzhou Patronus Biotech Co., Ltd. Active not recruiting No outcome recorded
Phase 2 NCT05775718 Oct 2023 → Jan 2028 expected University of Colorado, Denver Recruiting No outcome recorded
Phase 2 NCT05554068 Mar 2023 → Mar 2025 overdue herpes zoster Loyola University Recruiting No outcome recorded
Phase 2 NCT05082688 Sep 2021 → May 2023 herpes zoster, influenza Radboud University Medical Center Completed No outcome recorded
Phase 2 NCT04047979 Nov 2019 → Apr 2023 chickenpox, herpes zoster Emory University Completed No outcome recorded
Phase 2 NCT03894969 Apr 2019 → Aug 2020 respiratory system disorder GlaxoSmithKline Completed No outcome recorded
Phase 2 NCT03702231 Dec 2018 → Sep 2020 chronic lymphocytic leukemia/small lymphocytic lymphoma National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 2 NCT03604406 May 2014 → Jun 2024 herpes zoster, rheumatoid arthritis Kevin Winthrop Completed No outcome recorded
Phase 324 trials
Phase 3 NCT06001606 May 2023 → Apr 2025 herpes zoster, systemic lupus erythematosus Seoul National University Hospital Unknown No outcome recorded
Phase 3 NCT04128189 Mar 2023 → Jun 2029 expected chronic renal failure syndrome, herpes zoster University of Colorado, Denver Recruiting No outcome recorded
Phase 3 NCT04176939 Dec 2019 → Aug 2022 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT04091451 Sep 2019 → Feb 2024 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT03685682 May 2018 → Sep 2019 varicella zoster infection University Health Network, Toronto Completed No outcome recorded
Phase 3 NCT03439657 Apr 2018 → May 2019 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT02979639 Jan → Apr 2017 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT02723773 Apr 2016 → Jun 2023 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT02735915 Apr 2016 → Aug 2017 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 3 NCT02690207 Mar 2016 → Mar 2019 herpes zoster GlaxoSmithKline Completed No outcome recorded
Phase 413 trials
Phase 4 NCT07485283 Apr 2026 → Apr 2029 expected cardiovascular disorder, dementia Tor Biering-Sørensen Recruiting No outcome recorded
Phase 4 NCT07502560 Mar 2026 → Apr 2030 expected herpes zoster GlaxoSmithKline Recruiting No outcome recorded
Phase 4 NCT07280741 Dec 2025 → Jul 2027 expected rheumatic disorder University of Sao Paulo General Hospital Recruiting No outcome recorded
Phase 4 NCT06763783 Dec 2024 → Dec 2029 expected juvenile chronic polyarthritis, polymyalgia rheumatica, psoriatic arthritis, scleroderma +3 Region Skane Enrolling by invitation No outcome recorded
Phase 4 NCT06162494 Mar 2024 → Mar 2027 expected varicella zoster infection Ann & Robert H Lurie Children's Hospital of Chicago Enrolling by invitation No outcome recorded
Phase 4 NCT05898464 Jun 2023 → Feb 2026 Seoul National University Hospital Completed No outcome recorded
Phase 4 NCT05575830 Dec 2022 → Apr 2025 overdue Calmy Alexandra Active not recruiting No outcome recorded
Phase 4 NCT05596526 Dec 2022 → Dec 2024 herpes zoster Prof Patrice Lalive Unknown No outcome recorded
Phase 4 NCT05170399 Sep 2022 → Aug 2026 overdue lymphoma National Heart, Lung, and Blood Institute (NHLBI) Recruiting No outcome recorded
Phase 4 NCT04403139 Apr 2022 → Dec 2026 expected varicella zoster infection University of Washington Active not recruiting No outcome recorded
Phase not applicable2 trials
NCT06262776 Mar 2024 → Dec 2026 expected immunodeficiency disease Central Adelaide Local Health Network Incorporated Recruiting No outcome recorded
NCT04516408 Apr 2021 → Sep 2023 herpes zoster, systemic lupus erythematosus RenJi Hospital Unknown No outcome recorded
Also used as a comparator or background therapy in 29 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 111 trials
Phase 1 NCT06874842 Comparator Mar 2025 → Feb 2026 overdue herpes zoster Guangzhou Patronus Biotech Co., Ltd. Recruiting No outcome recorded
Phase 1 NCT06409494 Comparator Jul 2024 → Jul 2025 overdue herpes zoster EuBiologics Co.,Ltd Active not recruiting No outcome recorded
Phase 1 NCT06375512 Comparator Jul 2024 → Feb 2026 herpes zoster Shenzhen Shenxin Biotechnology Co., Ltd Completed No outcome recorded
Phase 1 NCT06335849 Comparator Mar 2024 → Sep 2025 overdue herpes zoster Guangzhou Patronus Biotech Co., Ltd. Active not recruiting No outcome recorded
Phase 1 NCT05991427 Comparator Nov 2023 → Nov 2024 herpes zoster CanSino Biologics Inc. Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT07400003 Comparator Jan → May 2026 overdue herpes zoster Sinovac Biotech Co., Ltd Recruiting No outcome recorded
Phase 1/2 NCT06932523 Comparator Apr 2025 → Jun 2026 overdue herpes zoster Shanghai Institute Of Biological Products Recruiting No outcome recorded
Phase 1/2 NCT06801509 Comparator Feb → Nov 2025 overdue herpes zoster Sinocelltech Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT05703607 Comparator Jan 2023 → Sep 2025 herpes zoster Pfizer Terminated No outcome recorded
Phase 1/2 NCT05701800 Comparator Jan 2023 → Jun 2026 overdue herpes zoster ModernaTX, Inc. Active not recruiting No outcome recorded
Phase 27 trials
Phase 2 NCT07205796 Comparator May 2026 → Dec 2027 expected herpes zoster Shenzhen Shenxin Biotechnology Co., Ltd Not yet recruiting No outcome recorded
Phase 2 NCT07481604 Comparator Apr 2026 → Jan 2027 expected herpes zoster CHA Vaccine Institute Co., Ltd. Not yet recruiting No outcome recorded
Phase 2 NCT07354659 Comparator Jan 2026 → Mar 2027 expected herpes zoster CSPC Megalith Biopharmaceutical Co.,Ltd. Not yet recruiting No outcome recorded
Phase 2 NCT06581575 Comparator Oct 2024 → Aug 2026 overdue herpes zoster Immorna Biotherapeutics, Inc. Active not recruiting No outcome recorded
Phase 2 NCT05856084 Comparator May 2023 → Dec 2024 overdue herpes zoster MAXVAX Biotechnology Limited Liability Company Active not recruiting No outcome recorded
Phase 46 trials
Phase 4 NCT04748939 Comparator Jan → Dec 2025 overdue herpes zoster Tuen Mun Hospital Not yet recruiting No outcome recorded
Phase 4 NCT05550194 Background Mar 2023 → Aug 2026 overdue achalasia Vanderbilt University Medical Center Recruiting No outcome recorded
Phase 4 NCT05007041 Comparator Sep 2021 → Mar 2023 Duke University Completed No outcome recorded
Phase 4 NCT04169009 Comparator Jul 2020 → Mar 2023 herpes zoster University of Colorado, Denver Completed No outcome recorded
Phase 4 NCT03798691 Comparator May 2019 → Oct 2023 Crohn disease, herpes zoster, ulcerative colitis University of Wisconsin, Madison Completed No outcome recorded

Evidence & citations 19 cited values

Every value below carries the sentence it was read from. 96 sources stand behind the page.

FieldValueCited text
Known as VARICELLA ZOSTER VIRUS ENVELOPE GLYCOPROTEIN E ChEMBL registry synonym — accepted as the source's own label CHEMBL4297975
Known as 1437173A “the GSK Biologicals' HZ vaccine 1437173A administered on either a 0,2-; 0,6- or 0,12-month schedule” NCT01751165
Known as GSK1437173A “Male or female subjects, 18 years of age or older at the time of the first vaccination, received 3 doses of GSK 1437173A formulation 1 (F1) vaccine, administered...” NCT00920218
36

“The purpose of this observer-blind study is to evaluate the safety and immunogenicity of GlaxoSmithKline Biologicals' investigational Herpes Zoster vaccine GSK1437173A when...” NCT00920218

“The purpose of this study is to assess the immunogenicity, safety, and reactogenicity of GSK Biologicals' Herpes Zoster (HZ) vaccine (GSK 1437173A) when administered...” NCT01777321

“Subjects, aged 18 years or older, received 2 doses of the GSK 1437173A vaccine, adjuvanted with AS01B at Day 0, and Month 1, administered intramuscularly, in the deltoid muscle...” NCT02058589

“Subjects received 2 doses of the candidate HZ vaccine GSK 1437173A, administered intramuscularly (IM) in deltoid region of non-dominant arm, according to a 0, 1 Month schedule.” NCT01610414

“Subjects received one dose of the GSK1437173A study vaccine and one dose of the Pneumovax™ 23 vaccine at Day 0 and a second dose of GSK1437173A study vaccine at Month 2.” NCT02045836

“Study to Evaluate Safety and Immunogenicity of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A in Adults Aged 18 Years and Older With Haematologic Malignancies” NCT01767467

“Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With Boostrix® in Adults Aged 50 Years and Older” NCT02052596

“Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years” NCT04869982

“Shingrix GSK's lyophilized formulation of the herpes zoster (HZ) vaccine (GSK1437173A)” NCT03894969

“GSK Biologicals Herpes Zoster subunit (HZ/su) vaccine (GSK 1437173A)” NCT02581410

“GSK Biologicals Herpes Zoster subunit (HZ/su) vaccine (GSK 1437173A)” NCT02979639

“candidate Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A)” NCT02979639

“Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A)” NCT02690207

“Biological: Herpes Zoster vaccine GSK 1437173A” NCT02052596

“Herpes Zoster vaccine GSK 1437173A” NCT01954251

“Herpes Zoster Vaccine GSK1437173ANCT01954251

NCT01165203

NCT01165177

NCT01165229

NCT02045836

NCT02075515

NCT01777321

NCT01086449

NCT00802464

NCT02058589

NCT04091451

NCT01767467

NCT02735915

NCT00434577

NCT01751165

NCT03439657

NCT01798056

NCT01610414

NCT02723773

NCT04176939

NCT02690207

Known as Herpes Zoster Vaccine Herpes Zoster Vaccine GSK1437173A” NCT02723773
Known as Herpes Zoster vaccine (GSK1437173A) ClinicalTrials.gov intervention name — accepted as the source's own label NCT01827839
Known as Herpes Zoster Vaccine 1437173A “Safety & Immunogenicity of GlaxoSmithKline Biologicals' Herpes Zoster Vaccine 1437173ANCT00920218
Known as HZ/su “The impact of alternate routes of vaccine administration, subcutaneous (SC) or intramuscular (IM), on the safety and immunogenicity of herpes zoster subunit candidate vaccine...” PMID 27936344 Dec 2016
3

“assessed whether (re)vaccination with the adjuvanted HZ subunit vaccine candidate (HZ/su) induced comparable immune responses in previous ZVL recipients and ZVL-naive...” PMID 29029122 Dec 2017

“2 doses of a herpes zoster (HZ) subunit vaccine (HZ/su; 50 µg varicella-zoster virus glycoprotein E [gE] and AS01B Adjuvant System)” PMID 29174683 Nov 2017

“Herpes Zoster subunit (HZ/su) vaccine (GSK1437173A)” NCT04091451

Known as HZ/su vaccine HZ/su vaccine (GSK1437173A)” NCT04176939
Known as Recombinant Herpes Zoster Vaccine Recombinant Herpes Zoster Vaccine (Shingrix)” NCT07485283
Known as Recombinant varicella zoster virus (vzv) glycoprotein e ChEMBL registry synonym — accepted as the source's own label CHEMBL4297975
Known as Recombinant zoster vaccine “Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years” NCT04869982
11

“The recombinant zoster vaccine (RZV, Shingrix®) has shown high efficacy in immunocompetent adults.” NCT07443709

Recombinant Zoster Vaccine (CHO cell),two-dose vaccination schedule (Month 0, 2)” NCT07354659

“Two doses of recombinant zoster vaccine(Shingrix®), 2 months apart” NCT05898464

NCT05718037

NCT07614412

NCT06162494

NCT05575830

NCT05596526

NCT04516408

NCT07502560

NCT07280741

Known as Recombinant zoster vaccine adjuvanted Recombinant zoster vaccine adjuvanted (SHINGRIX)” NCT06262776
Known as RZV “The recombinant subunit herpes zoster vaccine (RZV) is indicated for VZV-seropositive persons to prevent shingles but could potentially also protect VZV-seronegative persons...” PMID 33528118 Oct 2021
8

“the adjuvanted recombinant zoster vaccine (RZV) demonstrated >90% efficacy (VE) against herpes zoster (HZ) in adults ≥50 years of age (YOA)” PMID 33606577 Feb 2021

“We evaluated immunogenicity and safety of the adjuvanted recombinant zoster vaccine (RZV) in previous ZVL recipients.” PMID 32103273 Oct 2021

“Recombinant zoster vaccine (RZV) is indicated for prevention of herpes zoster in adults aged ≥ 50 years old.” NCT04516408

“The recombinant zoster vaccine (RZV, Shingrix®) has shown high efficacy in immunocompetent adults.” NCT07443709

“two doses of the adjuvanted recombinant Zoster vaccine (RZV, or Shingrix®)” NCT05596526

“Intervention 1: Recombinant Zoster Vaccine (Shingrix; RZV)” NCT07614412

“Recombinant Zoster Vaccine (RZV)” NCT07280741

NCT04869982

Known as Shingrix “A double-blind randomized controlled trial on the safety and immunogenicity of the recombinant subunit herpes zoster vaccine, Shingrix, in patients with rheumatic diseases...” NCT04748939
54

“A non-live, recombinant subunit Herpes zoster vaccine (Shingrix; GSK vaccines) was recently licensed for the prevention of shingles in people aged 50 years or older and was...” NCT03685682

“Following the initial approval of the GlaxoSmithKline (GSK) Biologicals' HZ/su vaccine, the protocol was amended to indicate that the trademark is Shingrix.” NCT03439657

“A non-live, recombinant subunit vaccine (Shingrix; GSK vaccines) was recently licensed for the prevention of shingles in people aged 50 years or older.” NCT03493776

“Participants aged 50 years and older will be vaccinated with 2 doses of Shingrix® on a 0, 2 month schedule, administered intramuscularly (IM).” NCT05856084

“Participants aged 50 years and older will be vaccinated with 2 doses of Shingrix® on a 0, 2 month schedule, administered intramuscularly (IM).” NCT07311148

“Subjects aged 50 years and older will be vaccinated with 2 doses of Shingrix® on a 0, 2 month schedule, administered intramuscularly (IM).” NCT06874842

“Subjects aged 50 years and older will be vaccinated with 2 doses of Shingrix® on a 0, 2 month schedule, administered intramuscularly (IM).” NCT05636436

“Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years” NCT04869982

“all participants will receive 2 doses of recombinant zoster vaccine (Shingrix)” NCT06162494

“Two doses of recombinant zoster vaccine(Shingrix®), 2 months apart” NCT05898464

“Intervention 1: Recombinant Zoster Vaccine (Shingrix; RZV)” NCT07614412

“Varicella Zoster Vaccine (Shingrix)” NCT03604406

“Treatment 5 (Shingrix)” NCT04210752

Shingrix®” NCT07400003

NCT04169009

NCT07481604

NCT05701800

NCT04523246

NCT05007041

NCT03771157

NCT06335849

NCT05871541

NCT03591770

NCT06375512

NCT05082688

NCT05580458

NCT07485283

NCT06763783

NCT03894969

NCT05554068

NCT06137755

NCT06801509

NCT05245838

NCT04128189

NCT05304351

NCT07205796

NCT03886038

NCT05769049

NCT05170399

NCT06581575

NCT03798691

NCT05550194

NCT05991427

NCT06932523

NCT06262776

NCT05703607

NCT06001606

NCT06409494

NCT07285265

NCT04403139

NCT06569823

NCT03953196

NCT07443709

NCT04047979

Known as SRX “The study plans to learn more about how the shingles vaccine, Shingrix (SRX), successfully prevents shingles in older people.” NCT04169009
Known as Zoster Vaccine Recombinant ClinicalTrials.gov intervention name — accepted as the source's own label NCT05775718
Known as Zoster Vaccine Recombinant, Adjuvanted Zoster Vaccine Recombinant, Adjuvanted (Shingrix)” NCT05991427
2

NCT03702231

NCT05718037

Modality Vaccine “GSK1437173A is the lead GSK candidate Herpes Zoster (HZ) vaccine to prevent episodes of HZ (shingles).” NCT00434577
Route Intramuscular “administered intramuscularly” NCT00802464