Drugs / Atosiban
Atosiban
also known as
Tractocile · Antocile · Antocin · Antocin ii · Atosiban (as acetate) · ATOSIBAN ACETATE · Atosiban sun · CAP-449 · +7 more
Other / unclassified targets OXTR via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Tractocile | — | 2000-01-20 | europa.eu ↗ |
Trials 14
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT07140237 | Sep → Dec 2025 overdue | — | University of Electronic Science and Technology of China | Recruiting | No outcome recorded |
| Phase 0 | NCT07093060 | Jun → Nov 2025 overdue | — | University of Electronic Science and Technology of China | Recruiting | No outcome recorded |
| Phase 12 trials · 1 missed | ||||||
| Phase 1 | NCT02893722 | Jan 2017 → Jan 2018 | pregnancy loss, recurrent, 4 | Shanghai First Maternity and Infant Hospital | Unknown | Missed primary |
| Phase 1 | NCT00679705 | May → Nov 2008 | — | University Hospital, Ghent | Completed | No outcome recorded |
| Phase 22 trials | ||||||
| Phase 2 | NCT05382143 | Feb → Jun 2022 | endometriosis | Radboud University Medical Center | Unknown | No outcome recorded |
| Phase 2 | NCT00587327 | Nov 2007 → May 2008 | — | Ferring Pharmaceuticals | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT02725736 | Mar 2016 → Mar 2018 | — | Tel-Aviv Sourasky Medical Center | Unknown | No outcome recorded |
| Phase 42 trials | ||||||
| Phase 4 | NCT05693688 | Dec 2017 → Feb 2024 | — | Academic Medical Center - University of Amsterdam | Completed | No outcome recorded |
| Phase 4 | NCT00599898 | Jan 2008 → Dec 2011 | — | Raed Salim | Completed | No outcome recorded |
| Phase not applicable5 trials | ||||||
| — | NCT07185230 | Dec 2025 → Jun 2027 expected | female infertility | Northwest Women's and Children's Hospital, Xi'an, Shaanxi | Recruiting | No outcome recorded |
| — | NCT03904745 | Dec 2020 → Jul 2021 | female infertility | Bezmialem Vakif University | Unknown | No outcome recorded |
| — | NCT06537778 | Jan 2018 → Feb 2024 | cervix disorder | Children's Hospital of Chongqing Medical University | Completed | No outcome recorded |
| — | NCT03570294 | Feb 2014 → Jun 2018 | — | Polish Mother Memorial Hospital Research Institute | Completed | No outcome recorded |
| — | NCT01493440 | Mar → Aug 2011 | infertility disorder | An Sinh Hospital | Completed | No outcome recorded |
| Comparator or background therapy7 trials | ||||||
| Phase 2 | NCT03369262 Background | Jan 2018 → Jul 2020 | — | ObsEva SA | Unknown | No outcome recorded |
| Phase 2 | NCT01429545 Comparator | Apr 2007 → Sep 2010 | — | Tawam Hospital | Completed | No outcome recorded |
| Phase 3 | NCT02292784 Comparator | Jun 2015 → Sep 2019 | pregnancy disorder | GlaxoSmithKline | Completed | No outcome recorded |
| Phase 3 | NCT02292771 Comparator | Mar 2015 → Aug 2017 | pregnancy disorder | GlaxoSmithKline | Terminated | Missed primary Stop: Enrollment |
| Phase 3 | NCT01314859 Comparator | Jul 2011 → Jul 2012 | — | Hospital Clinico Universitario de Santiago | Withdrawn | No outcome recorded |
| Phase 4 | NCT01673399 Comparator | Feb 2012 → Feb 2015 | low implantation of placenta | AZ Jan Palfijn Gent | Completed | No outcome recorded |
| Phase 4 | NCT01501214 Comparator | Dec 2011 → Dec 2013 | female infertility | The University of Hong Kong | Completed | No outcome recorded |
Evidence & citations 20 cited values
Every value below carries the sentence it was read from. 22 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | atosiban | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01493440 ↗ |
| Known as | Antocile | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | Antocin | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | Antocin ii | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | Atosiban (as acetate) | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | ATOSIBAN ACETATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | Atosiban sun | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | CAP-449 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | CAP-476 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | CAP-581 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | F-314 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | ORF 22164 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | RW-22164 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | RWJ 22164 | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | Tractocil | ChEMBL registry synonym — accepted as the source's own label CHEMBL382301 ↗ |
| Known as | Tractocile | “Participants allocated to the Atosiban group will be administered Atosiban (37.5 mg/5 mL, Tractocile®, Ferring Pharma, Geneva, Switzerland)” NCT07185230 ↗1“Atosiban (Tractocile), maximum 300 µg/minute, IV” NCT00679705 ↗ |
| Action | Inhibit | “mixed oxytocin antagonist - vasopressin V1a antagonist (atosiban)” NCT00587327 ↗1“Oxytocin receptor antagonist” CHEMBL382301 ↗ |
| Modality | Other / unclassified | “atosiban (oxytocin antagonist)” NCT01429545 ↗ |
| Route | Intravenous | “Solution for IV administration.” NCT00587327 ↗ |
| Target | OXTR | “Oxytocin receptor antagonist” CHEMBL382301 ↗ |