Drugs / Diethylstilbestrol
Diethylstilbestrol
also known as
Apstil · DES · Dietilestilbestrol · Distilbene · NSC-3070 · Stilbestro · Stilbestrol · Stilbetin · +2 more
Small molecule targets ESR1 via activation
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | STILBESTROL | — | 1973-05-30 | fda.gov ↗ |
Trials 2
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT00136526 | Dec 2002 → Oct 2007 | prostate cancer | University of Washington | Completed | No outcome recorded |
| Phase 31 trial · 1 missed | ||||||
| Phase 3 | NCT00316927 | Dec 2002 → Apr 2007 | prostate cancer | St. Bartholomew's Hospital | Completed | Missed primary |
Evidence & citations 15 cited values
Every value below carries the sentence it was read from. 3 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | diethylstilbestrol | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00316927 ↗ |
| Known as | Apstil | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | DES | “Docetaxel and Diethylstilbestrol (DES)” NCT00136526 ↗ |
| Known as | Dietilestilbestrol | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | Distilbene | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | NSC-3070 | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | Stilbestro | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | Stilbestrol | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | Stilbetin | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | Stilboesterol | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Known as | Tampovagan | ChEMBL registry synonym — accepted as the source's own label CHEMBL411 ↗ |
| Action | Activate | “Estrogen receptor alpha agonist” CHEMBL411 ↗ |
| Modality | Small molecule | — CHEMBL411 ↗ |
| Route | Oral | “Subsequent to treatment failure with DA, patients continue to receive DA as before in addition to oral diethylstilbestrol once daily (DAS).” NCT00316927 ↗ |
| Target | ESR1 | “Estrogen receptor alpha agonist” CHEMBL411 ↗ |