Drugs / 2-hydroxypropyl-beta-cyclodextrin
2-hydroxypropyl-beta-cyclodextrin
also known as
Hydroxypropyl Beta Cyclodextrin · HPβCD · 2-hydroxypropyl-β-cyclodextrin · 2HPBCD · HP-Beta-CD · Hpbcd · Hydroxyl-propyl-beta-cyclodextrin · Hydroxypropyl bcd · +4 more
Trials 4
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 22 trials | ||||||
| Phase 2 | NCT05607615 | Sep 2022 → Mar 2024 | Alzheimer disease | Cyclo Therapeutics, Inc. | Unknown | No outcome recorded |
| Phase 2 | NCT00914745 | Apr 2009 → May 2010 | herpes labialis | University of Zurich | Completed | No outcome recorded |
| Phase 31 trial | ||||||
| Phase 3 | NCT04860960 | Jul 2021 → Jun 2025 | Niemann-Pick disease, type C1 | Cyclo Therapeutics, Inc. | Unknown | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT01960621 | Aug 2016 → Aug 2017 | — | Imperial College London | Withdrawn | No outcome recorded |
| Comparator or background therapy2 trials | ||||||
| Phase 1 | NCT02939547 Comparator | Oct 2017 → Feb 2020 | Niemann-Pick disease, type C1 | Cyclo Therapeutics, Inc. | Completed | No outcome recorded |
| Phase 1/2 | NCT02912793 Comparator | Mar 2017 → Mar 2021 | Niemann-Pick disease, type C1 | Cyclo Therapeutics, Inc. | Completed | No outcome recorded |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 9 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | 2-hydroxypropyl-beta-cyclodextrin | “The investigators want to see whether the test drug in this research study, 2-hydroxypropyl-beta-cyclodextrin (2HPBCD), might potentially be able to improve cough in healthy volunteers.” NCT01960621 ↗ |
| Known as | 2-hydroxypropyl-β-cyclodextrin | “Preclinical studies have demonstrated that systemically administered 2-hydroxypropyl-β-cyclodextrin (HPβCD; Trappsol® Cyclo™) restores cholesterol metabolism and homeostasis in...” PMID 36279795 ↗ Oct 2022 |
| Known as | 2HPBCD | “The investigators want to see whether the test drug in this research study, 2-hydroxypropyl-beta-cyclodextrin (2HPBCD), might potentially be able to improve cough in healthy volunteers.” NCT01960621 ↗ |
| Known as | HP-Beta-CD | “A Phase I Study to Evaluate the Single and Multiple-dose Pharmacokinetics of Intravenous Trappsol Cyclo (HP-Beta-CD) in Patients With Niemann-Pick Disease Type C (NPC-1) and...” NCT02939547 ↗ |
| Known as | Hpbcd | ChEMBL registry synonym — accepted as the source's own label CHEMBL577294 ↗ |
| Known as | HPβCD | “Preclinical studies confirmed a critical role of systemically administered hydroxypropyl-β-cyclodextrin (HP-β-CD; Trappsol® Cyclo™) in cholesterol metabolism and homeostasis in...” PMID 37670901 ↗ Jun 20231“Preclinical studies have demonstrated that systemically administered 2-hydroxypropyl-β-cyclodextrin (HPβCD; Trappsol® Cyclo™) restores cholesterol metabolism and homeostasis in...” PMID 36279795 ↗ Oct 2022 |
| Known as | Hydroxyl-propyl-beta-cyclodextrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL577294 ↗ |
| Known as | Hydroxypropyl bcd | ChEMBL registry synonym — accepted as the source's own label CHEMBL577294 ↗ |
| Known as | Hydroxypropyl Beta Cyclodextrin | “Single Center Phase I/II, Placebo Controlled, Randomized, Double-Blind Study to Treat Recurrent Herpes Labialis by Topical Treatment With...” NCT00914745 ↗ |
| Known as | Hydroxypropyl betadex | ChEMBL registry synonym — accepted as the source's own label CHEMBL577294 ↗ |
| Known as | Hydroxypropyl-bcyclodextrin | ChEMBL registry synonym — accepted as the source's own label CHEMBL577294 ↗ |
| Known as | Hydroxypropyl-beta-cyclodextrin (HP-β-CD) | “Hydroxypropyl-beta-cyclodextrin (HP-β-CD)” NCT02939547 ↗ |
| Known as | Trappsol Cyclo | “Preclinical studies have demonstrated that systemically administered 2-hydroxypropyl-β-cyclodextrin (HPβCD; Trappsol® Cyclo™) restores cholesterol metabolism and homeostasis in...” PMID 36279795 ↗ Oct 2022 |
| Route | Intravenous | “Treatment will be administered every two weeks by slow IV infusion” NCT02912793 ↗ |