Drugs / Tonabersat
last change Jan 2026 re-read 3 minutes ago

Tonabersat

also known as SB-220453 · Tonabersate

Small molecule

Developed for
migraine with aura · migraine without aura · long COVID-19 · diabetic macular edema
Investigated by
Minster Research Ltd · Inflammx Therapeutics Inc · University of Copenhagen

Trials 4

2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 24 trials · 1 missed
Phase 2 NCT06437223 Mar 2024 → Sep 2025 long COVID-19 Inflammx Therapeutics Inc Completed No outcome recorded
Phase 2 NCT00534560 Oct 2007 → Nov 2008 migraine with aura, migraine without aura Minster Research Ltd Completed No outcome recorded
Phase 2 NCT00332007 May 2006 → Aug 2008 migraine with aura Minster Research Ltd Completed Mixed
Phase 2 NCT00311662 Apr → Oct 2006 migraine with aura, migraine without aura Minster Research Ltd Completed Missed primary
Comparator or background therapy1 trial
Phase 2 NCT05727891 Comparator May 2023 → Jun 2025 overdue diabetic macular edema Jaeb Center for Health Research Active not recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as Tonabersat ClinicalTrials.gov intervention name — accepted as the source's own label NCT00311662 ↗
4

NCT00332007 ↗

NCT00534560 ↗

NCT05727891 ↗

NCT06437223 ↗

Known as SB-220453 ChEMBL registry synonym — accepted as the source's own label CHEMBL318191 ↗
Known as Tonabersate ChEMBL registry synonym — accepted as the source's own label CHEMBL318191 ↗
Action Inhibit “Connexin43 hemichannel inhibitor” NCT05727891 ↗
Modality Small molecule — CHEMBL318191 ↗
Route Oral “Tablets” NCT00534560 ↗