drugset
Drugs / PF-05212377
last change Mar 2023 re-read 9 days ago

PF-05212377

also known as SAM-760 · PF-5212377 · WYE-103760

Small molecule targets HTR6 via inhibition

Developed for
Alzheimer disease
Investigated by
Pfizer · Yale University

Trials 6

today NCT02005991 · Ph 1 NCT01712074 · Ph 2 NCT01213355 · Ph 1 NCT01258751 · Ph 1 NCT01159496 · Ph 1 NCT00948662 · Ph 1
201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 15 trials
Phase 1 NCT02005991 Nov 2013 → Jan 2014 — Pfizer Completed No outcome recorded
Phase 1 NCT01213355 Apr → Aug 2011 — Pfizer Completed No outcome recorded
Phase 1 NCT01258751 Dec 2010 → May 2011 — Pfizer Completed No outcome recorded
Phase 1 NCT01159496 Jul → Dec 2010 — Pfizer Completed No outcome recorded
Phase 1 NCT00948662 Sep 2009 → Dec 2010 — Pfizer Completed No outcome recorded
Phase 21 trial · 1 missed
Phase 2 NCT01712074 Nov 2012 → Sep 2015 Alzheimer disease Pfizer Terminated Missed primary

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 9 sources stand behind the page.

FieldValueCited text
Known as PF-05212377 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01712074 ↗
4

NCT01258751 ↗

NCT02005991 ↗

NCT01159496 ↗

NCT01213355 ↗
Known as PF-5212377 ChEMBL registry synonym — accepted as the source's own label CHEMBL3329435 ↗
Known as SAM-760 “A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer's disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil.” PMID 29622037 ↗ Apr 2018
4

“PF-05212377 (SAM760) is a potent and selective 5-HT6 antagonist, previously under development for the treatment of Alzheimer's disease.” PMID 36825693 ↗ Mar 2023

“PF-05212377 (SAM-760), A 5-HT6 Antagonist” NCT01213355 ↗

“PF-05212377 (SAM-760)” NCT01159496 ↗

NCT00948662 ↗
Known as WYE-103760 ChEMBL registry synonym — accepted as the source's own label CHEMBL3329435 ↗
Action Inhibit “Serotonin 6 (5-HT6) receptor antagonist” CHEMBL3329435 ↗
1

“5-HT6 Antagonist” NCT01213355 ↗
Modality Small molecule — CHEMBL3329435 ↗
Route Oral “ascending single oral doses of SAM-760” NCT00948662 ↗
Target HTR6 “Serotonin 6 (5-HT6) receptor antagonist” CHEMBL3329435 ↗