Drugs / JNJ-74856665
last change Aug 2025 re-read 2 minutes ago

JNJ-74856665

targets DHODH via inhibition

Developed for
acute myeloid leukemia · myelodysplastic syndrome · chronic myelomonocytic leukemia
Investigated by
Janssen Research & Development, LLC

Trials 2 · a red edge is where a trial was stopped

20212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT06788509 Dec 2024 → Jan 2028 expected B-cell chronic lymphocytic leukemia, acute myeloid leukemia, castration-resistant prostate carcinoma, myelodysplastic syndrome Janssen Research & Development, LLC Enrolling by invitation No outcome recorded
Phase 1 NCT04609826 Nov 2020 → Aug 2025 acute myeloid leukemia, chronic myelomonocytic leukemia, myelodysplastic syndrome Janssen Research & Development, LLC Completed No outcome recorded

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 2 sources stand behind the page.

FieldValueCited text
Known as JNJ-74856665 ClinicalTrials.gov intervention name — accepted as the source's own label NCT04609826
1

NCT06788509

Action Inhibit “JNJ-74856665 is an orally bioavailable, potent, and selective dihydroorotate dehydrogenase (DHODH) inhibitor” NCT04609826
Route Oral “JNJ-74856665 will be administered orally.” NCT04609826
Target DHODH “JNJ-74856665 is an orally bioavailable, potent, and selective dihydroorotate dehydrogenase (DHODH) inhibitor” NCT04609826