Drugs / Trihexyphenidyl
Trihexyphenidyl
also known as
Agitane · Aparkane · Apo-trihex · Artane · Bentex · Benzhexol hydrochloride · Broflex · Cyclodol · +14 more
Small molecule targets CHRM1 via inhibition
Regulatory milestones approvals, filings & regulatory actions · 2 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Label expansion | US (FDA) | ARTANE | — | 1977-02-08 | fda.gov ↗ |
| Approved | US (FDA) | ARTANE | — | 1949-05-13 | fda.gov ↗ |
Trials 2
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| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 11 trial | ||||||
| Phase 1 | NCT06554288 | Oct 2024 → Nov 2029 expected | cerebral palsy, dystonic disorder | Children's Mercy Hospital Kansas City | Recruiting | No outcome recorded |
| Phase 21 trial | ||||||
| Phase 2 | NCT00122044 | Jan 2003 → Dec 2004 | dystonic disorder | University of Southern California | Completed | No outcome recorded |
| Comparator or background therapy3 trials | ||||||
| Phase 0 | NCT03430596 Comparator | May 2018 → Oct 2021 | extrapyramidal and movement disease | Shanghai Mental Health Center | Completed | No outcome recorded |
| Phase 2 | NCT06328114 Comparator | Dec 2024 → Jul 2029 expected | cervical dystonia | Duke University | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT04523935 Comparator | Dec 2005 → Aug 2020 | cerebral palsy | Sathbhavana Brain Clinic | Completed | No outcome recorded |
Evidence & citations 26 cited values
Every value below carries the sentence it was read from. 6 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | trihexyphenidyl | ClinicalTrials.gov intervention name — accepted as the source's own label NCT06328114 ↗ |
| Known as | Agitane | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Aparkane | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Apo-trihex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Artane | “Baclofen(Liofen®),Diazepam,(Valium®),Clonazepam,(Klonopin®),Trihexyphenidyl(Artane®),Tetrabenazine(Xenazine®),Gabapentin(Neurontin®),Topiramate(Topamax®),Lamotrigine(Lamictal®),...” NCT04523935 ↗ |
| Known as | Bentex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Benzhexol hydrochloride | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Broflex | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Cyclodol | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Cyclodolum | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | NSC-12268 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | NSC-757357 | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Parcopane | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Romparkin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Sedrina | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | THP | “evaluate the pharmacokinetics (PK) of trihexyphenidyl (THP) and variation in PK parameters between CYP2D6 and CYP2C19 genotypes and 2) evaluate the feasibility of a future...” NCT06554288 ↗ |
| Known as | Tremin | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Trihexifenidilo | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Trihexyphenidyl hcl | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Trihexyphenidyl hydrochloride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT03430596 ↗ |
| Known as | Trihexyphenidyle | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Trihexyphenidyli hydrochloridum | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Known as | Triphedinon | ChEMBL registry synonym — accepted as the source's own label CHEMBL1490 ↗ |
| Action | Inhibit | “Muscarinic acetylcholine receptor M1 antagonist” CHEMBL1490 ↗ |
| Modality | Small molecule | — CHEMBL1490 ↗ |
| Target | CHRM1 | “Muscarinic acetylcholine receptor M1 antagonist” CHEMBL1490 ↗ |