Drugs / FLINDOKALNER
Trials 1
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase not applicable1 trial · 1 met primary | ||||||
| — | NCT05378074 | Sep 2022 → Dec 2023 | traumatic encephalopathy | Danish Headache Center | Unknown | Met primary |
| Comparator or background therapy1 trial | ||||||
| — | NCT03887325 Comparator | Apr 2019 → Feb 2020 | migraine disorder | Danish Headache Center | Completed | No outcome recorded |
Evidence & citations 11 cited values
Every value below carries the sentence it was read from. 5 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | FLINDOKALNER | ChEMBL registry synonym — accepted as the source's own label CHEMBL266510 ↗ |
| Known as | BMS 204352 | “Maxipost (BMS 204352) is a vasoactive molecule that causes vasodilation via the big calcium dependent potassium (BKCa) channel signaling pathway.” NCT03887325 ↗ |
| Known as | BMS-204352-01 | ChEMBL registry synonym — accepted as the source's own label CHEMBL266510 ↗ |
| Known as | MaxiPost | “Maxipost (BMS 204352) is a vasoactive molecule that causes vasodilation via the big calcium dependent potassium (BKCa) channel signaling pathway.” NCT03887325 ↗ |
| Action | Activate | “MaxiPost, a large (big)-conductance calcium-activated potassium (BKCa) channel opener” PMID 34252916 ↗ Oct 20214“Calcium-activated potassium channel subunit alpha-1 opener” CHEMBL266510 ↗ “Voltage-gated potassium channel subunit Kv7.4 activator” CHEMBL266510 ↗ “Voltage-gated potassium channel subunit Kv7.2 activator” CHEMBL266510 ↗ “Voltage-gated potassium channel subunit Kv7.5 activator” CHEMBL266510 ↗ |
| Modality | Small molecule | — CHEMBL266510 ↗ |
| Route | Intravenous | “intravenous infusion of 0.05 mg/min BKCa channel opener MaxiPost” PMID 32847403 ↗ Aug 2020 |
| Target | KCNMA1 | “Calcium-activated potassium channel subunit alpha-1 opener” CHEMBL266510 ↗ |
| Target | KCNQ2 | “Voltage-gated potassium channel subunit Kv7.2 activator” CHEMBL266510 ↗ |
| Target | KCNQ4 | “Voltage-gated potassium channel subunit Kv7.4 activator” CHEMBL266510 ↗ |
| Target | KCNQ5 | “Voltage-gated potassium channel subunit Kv7.5 activator” CHEMBL266510 ↗ |