Hypersensitivity to Opening of BKCa Channels in Post-Traumatic Headache

Unknown 21 enrolled Danish Headache Center

RandomizedCrossoverQuadruple-blindBasic science

Summary

The aim is to investigate whether opening of large conductance calcium-activated potassium (BKCa) channels induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).

Timeline

Start: 2022-09-01
Primary completion: 2023-12-31
Completion: 2023-12-31

Outcome

Met primary endpoint

paper 11 (52%) of 21 participants after MaxiPost infusion, in contrast to four (19%) participants following placebo (P = .02). PMID 38890563 ↗

Publications

Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Melchior AG, Burstein R, Ashina H. Hypersensitivity to BKCa channel opening in persistent post-traumatic headache. J Headache Pain. 2024 Jun 18;25(1):102. doi: 10.1186/s10194-024-01808-0.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	FLINDOKALNER	Small molecule	0.05 mg	Intravenous