Drugs / Physostigmine
Physostigmine
also known as
Antilirium · Cogmine · Eserin · Eserine hemisulfate salt · Eserinum · MCV-4484 · NSC-30782 · NSC-757275 · +7 more
Small molecule targets ACHE via inhibition
Trials 5 · a red edge is where a trial was stopped
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 01 trial | ||||||
| Phase 0 | NCT00689208 | May 2007 → Oct 2008 | — | AstraZeneca | Completed | No outcome recorded |
| Phase 41 trial | ||||||
| Phase 4 | NCT03090620 | Mar 2017 → Jul 2020 | poisoning | University of Colorado, Denver | Completed | No outcome recorded |
| Phase not applicable3 trials | ||||||
| — | NCT02008292 | Sep 2013 → Dec 2021 | schizophrenia | Yale University | Completed | No outcome recorded |
| — | NCT01121497 | Jul 2010 → Jul 2011 | cognitive disorder | Rabin Medical Center | Unknown | No outcome recorded |
| — | NCT01171118 | Aug 2009 → Aug 2011 | — | University of Rochester | Completed | No outcome recorded |
Also used as a comparator or background therapy in 4 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 32 trials | ||||||
| Phase 3 | NCT02216266 Comparator | Apr 2014 → Dec 2018 | subacute delirium | PD Dr. Bertram Scheller | Unknown | No outcome recorded |
| Phase 3 | NCT01394445 Comparator | Jun → Dec 2011 | — | Medical University of Graz | Completed | No outcome recorded |
| Phase not applicable2 trials | ||||||
| — | NCT03013322 Comparator | Jan 2015 → Feb 2017 | infectious disease with sepsis | University Hospital Heidelberg | Completed | No outcome recorded |
| — | NCT00850850 Comparator | Dec 2009 → Mar 2011 | — | Bispebjerg Hospital | Unknown | No outcome recorded |
Evidence & citations 20 cited values
Every value below carries the sentence it was read from. 10 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Physostigmine | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00689208 ↗ |
| Known as | Antilirium | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Cogmine | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Eserin | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Eserine hemisulfate salt | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Eserinum | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | MCV-4484 | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | NSC-30782 | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | NSC-757275 | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Physostigmine monosalicylate | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | physostigmine salicylate | “The treatment group receives an infusion of 0.04 mg/kg physostigmine salicylate with a maximum dose of 4 mg.” NCT03013322 ↗ |
| Known as | PHYSOSTIGMINE SULFATE | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Physostigmine sulfate (2:1) | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Physostigmine sulphate | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Physostigmine sulphate (2:1) | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Known as | Physostigmini salicylas | ChEMBL registry synonym — accepted as the source's own label CHEMBL94 ↗ |
| Action | Inhibit | “centrally acting acetylcholinesterase inhibitor” NCT01171118 ↗1“Acetylcholinesterase inhibitor” CHEMBL94 ↗ |
| Modality | Small molecule | — CHEMBL94 ↗ |
| Route | Intravenous | “Intravenous bolus of physostigmine 1 mg, 3-5 minutes before completion of the colonoscopy procedure” NCT01121497 ↗ |
| Target | ACHE | “Acetylcholinesterase inhibitor” CHEMBL94 ↗ |