drugset
Drugs / HISTIDINE
last change Apr 2026 re-read 2 minutes ago

HISTIDINE

also known as L-histidine · FEMA NO. 3694 · Histidina · Histidine hydrochloride · HISTIDINE MONOHYDROCHLORIDE · NSC-137773 · NSC-257867 · Osmhydran ls 8453 · +3 more

Small molecule

Developed for
multiple sclerosis · Alzheimer disease
Investigated by
University of Miami · United States Department of Defense

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved EU (EMA) Maapliv — 2025-07-28 europa.eu ↗

Trials 2 · a red edge is where a trial was stopped

today
EU approved 2025
NCT04764383 · Ph 2 NCT03266965 · Ph 1
201820192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03266965 Mar 2018 → Aug 2020 multiple sclerosis University of Miami Completed No outcome recorded
Phase 21 trial
Phase 2 NCT04764383 Jan → Oct 2022 multiple sclerosis University of Miami Withdrawn No outcome recorded
Also used as a comparator or background therapy in 1 trial
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 4 NCT06169826 Comparator Apr 2025 → Apr 2026 Alzheimer disease Wake Forest University Health Sciences Withdrawn No outcome recorded

Evidence & citations 14 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as HISTIDINE ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as FEMA NO. 3694 ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as Histidina ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as Histidine hydrochloride ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as HISTIDINE MONOHYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as L-histidine “plus a titrated dosing of L-histidine powder or capsules starting at 2g consumed before noon escalating every 2 weeks up to 4, 6, then 8 g per day as tolerated for up to 3 months.” NCT06169826 ↗
3

“Dietary Supplement: L-Histidine” NCT03266965 ↗

NCT04764383 ↗

NCT06169826 ↗
Known as NSC-137773 ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as NSC-257867 ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as Osmhydran ls 8453 ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as P.p.a.a. ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as Photonyl ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Known as Sunactyl ls 9610 ChEMBL registry synonym — accepted as the source's own label CHEMBL17962 ↗
Modality Small molecule — CHEMBL17962 ↗
Route Oral “taken by mouth (PO)” NCT04764383 ↗