Drugs / balcinrenone
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balcinrenone

also known as AZD9977 · Balcinrenona

Small molecule targets NR3C2

Developed for
heart failure · chronic kidney disease · chronic renal failure syndrome
Investigated by
AstraZeneca · Parexel · Klinikum Nürnberg · Quotient Sciences

Trials 20 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 115 trials
Phase 1 NCT06979388 May → Jul 2025 AstraZeneca Completed No outcome recorded
Phase 1 NCT06651021 Oct 2024 AstraZeneca Completed No outcome recorded
Phase 1 NCT06388616 May → Sep 2024 AstraZeneca Completed No outcome recorded
Phase 1 NCT04798222 Jun → Sep 2021 heart failure AstraZeneca Completed No outcome recorded
Phase 1 NCT04686591 Dec 2020 → Feb 2021 cardiovascular disorder AstraZeneca Completed No outcome recorded
Phase 1 NCT04469907 Jun 2020 → Oct 2021 impaired renal function disease AstraZeneca Completed No outcome recorded
Phase 1 NCT03843060 Feb → Apr 2019 diastolic heart failure AstraZeneca Completed No outcome recorded
Phase 1 NCT03804645 Feb → Apr 2019 heart failure AstraZeneca Completed No outcome recorded
Phase 1 NCT03801967 Jan → May 2019 heart failure AstraZeneca Completed No outcome recorded
Phase 1 NCT03682497 Nov 2018 → Mar 2020 heart failure AstraZeneca Terminated No outcome recorded
Phase 23 trials
Phase 2 NCT06350123 May 2024 → May 2025 chronic kidney disease AstraZeneca Completed No outcome recorded
Phase 2 NCT05884866 Jul 2023 → Dec 2025 chronic renal failure syndrome, disorder of acid-base balance Klinikum Nürnberg Completed No outcome recorded
Phase 2 NCT04595370 Jan 2021 → Sep 2023 chronic kidney disease, heart failure AstraZeneca Completed No outcome recorded
Phase 32 trials
Phase 3 NCT07624305 Sep 2026 → Jul 2030 expected chronic kidney disease AstraZeneca Not yet recruiting No outcome recorded
Phase 3 NCT06307652 Apr 2024 → Jun 2027 expected heart failure AstraZeneca Recruiting No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 22 sources stand behind the page.

FieldValueCited text
Known as balcinrenone ClinicalTrials.gov intervention name — accepted as the source's own label NCT06979388
6

NCT06350123

NCT06388616

NCT05884866

NCT06307652

NCT06651021

NCT07624305

Known as AZD9977 “The aim of this phase 1 trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone (previously AZD9977) in participants with severe renal impairment vs....” PMID 39962632 Feb 2025
13

“Participants will receive oral AZD9977 Dose A capsule and 10 mg dapagliflozin tablet in fasted condition.” NCT04798222

AZD9977 is an oral, selective mineralocorticoid receptor (MR) modulator.” NCT03804645

NCT03435276

NCT03450759

NCT03801967

NCT04469907

NCT03843060

NCT02560363

NCT03682497

NCT02532998

NCT04686591

NCT02484729

NCT04595370

Known as Balcinrenona ChEMBL registry synonym — accepted as the source's own label CHEMBL3916929
Modality Small molecule CHEMBL3916929
Route Oral “AZD9977 as oral suspension” NCT02484729
Target NR3C2 “Mineralocorticoid receptor modulator” CHEMBL3916929