Drugs / atamparib
last change Feb 2026 re-read 2 minutes ago

atamparib

also known as RBN-2397 · ATAMPARIB (RBN-2397)

Small molecule targets TIPARP via inhibition

Developed for
cancer · lung adenocarcinoma · non-small cell squamous lung carcinoma
Investigated by
Ribon Therapeutics, Inc. · Nerviano Medical Sciences (Shanghai) Ltd.

Trials 3 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT04053673 Aug 2019 → Jun 2023 cancer Ribon Therapeutics, Inc. Unknown No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT07374419 Feb 2026 → Jul 2028 expected lung adenocarcinoma Nerviano Medical Sciences (Shanghai) Ltd. Not yet recruiting No outcome recorded
Phase 1/2 NCT05127590 Mar 2022 → Nov 2023 non-small cell squamous lung carcinoma Ribon Therapeutics, Inc. Unknown No outcome recorded

Evidence & citations 7 cited values

Every value below carries the sentence it was read from. 4 sources stand behind the page.

FieldValueCited text
Known as atamparib ClinicalTrials.gov intervention name — accepted as the source's own label NCT07374419
Known as ATAMPARIB (RBN-2397) ChEMBL registry synonym — accepted as the source's own label CHEMBL5095043
Known as RBN-2397 ClinicalTrials.gov intervention name — accepted as the source's own label NCT05127590
1

NCT04053673

Action Inhibit “RBN-2397 inhibits PARP7” NCT04053673
Modality Small molecule CHEMBL5095043
Route Oral “Continuous oral dosing with the RP2D of RBN-2397 (outpatient basis).” NCT05127590
Target PARP7 “RBN-2397 inhibits PARP7NCT04053673