Drugs / Abelacimab
last change Apr 2026 re-read 9 days ago

Abelacimab

Monoclonal antibody targets F11 via inhibition

Developed for
atrial fibrillation · pulmonary embolism · venous thromboembolism · stroke disorder
Investigated by
Anthos Therapeutics, Inc. · Novartis Pharmaceuticals

Trials 4

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial · 1 met primary
Phase 2 NCT04755283 Feb 2021 → Feb 2024 overdue atrial fibrillation, stroke disorder Anthos Therapeutics, Inc. Active not recruiting Met primary
Phase 33 trials
Phase 3 NCT05712200 Dec 2022 → Dec 2027 expected atrial fibrillation Anthos Therapeutics, Inc. Recruiting No outcome recorded
Phase 3 NCT05171075 Sep 2022 → Apr 2026 pulmonary embolism, venous thromboembolism Anthos Therapeutics, Inc. Terminated No outcome recorded Stop: Business
Phase 3 NCT05171049 May 2022 → Feb 2026 pulmonary embolism, venous thromboembolism Anthos Therapeutics, Inc. Terminated No outcome recorded Stop: Business

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 5 sources stand behind the page.

FieldValueCited text
Known as Abelacimab ClinicalTrials.gov intervention name — accepted as the source's own label NCT05171075 ↗
3

NCT05171049 ↗

NCT04755283 ↗

NCT05712200 ↗

Action Inhibit “binds to the inactive form of factor XI and blocks its activation” PMID 39842011 ↗ Jan 2025
Modality Monoclonal antibody “Abelacimab is a fully human monoclonal antibody” PMID 39842011 ↗ Jan 2025
Route Subcutaneous “subcutaneous injection of abelacimab” PMID 39842011 ↗ Jan 2025
Target F11 “binds to the inactive form of factor XI and blocks its activation” PMID 39842011 ↗ Jan 2025