Drugs / CYD-TDV
last change Nov 2019 re-read 2 minutes ago

CYD-TDV

also known as Dengvaxia · CYD dengue vaccine

Vaccine

Developed for
Dengue hemorrhagic fever
Investigated by
Sanofi Pasteur, a Sanofi Company · Sanofi

Trials 11 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 27 trials
Phase 2 NCT02824198 Jul 2016 → Mar 2017 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT01550289 Mar 2012 → Dec 2013 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT01488890 Dec 2011 → Sep 2013 Dengue hemorrhagic fever, yellow fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT01187433 Aug 2010 → Oct 2012 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT00993447 Oct 2009 → Sep 2011 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT00788151 Sep 2008 → Feb 2010 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 2 NCT00740155 Aug 2008 → Oct 2009 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 34 trials
Phase 3 NCT01374516 Jun 2011 → Nov 2014 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 3 NCT01373281 Jun 2011 → Aug 2014 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded
Phase 3 NCT01254422 Dec 2010 → Sep 2012 Dengue hemorrhagic fever Sanofi Completed No outcome recorded
Phase 3 NCT01134263 Oct 2010 → Nov 2012 Dengue hemorrhagic fever Sanofi Pasteur, a Sanofi Company Completed No outcome recorded

Evidence & citations 5 cited values

Every value below carries the sentence it was read from. 16 sources stand behind the page.

FieldValueCited text
Known as CYD-TDV “In a randomized, placebo-controlled, monocenter, observer blinded study conducted in an area where dengue is endemic, we assessed the safety and immunogenicity of a...” PMID 22863660 Jul 2012
10

“The tetravalent dengue vaccine (CYD-TDV; Dengvaxia®) is administered on a three-dose schedule, 6 months apart in those aged ≥9 years in a number of dengue-endemic countries in...” PMID 31464558 Nov 2019

“Two groups received an injection at each timepoint of a tetravalent blend of CYD-1;3;4 and a VERO cell derived, live attenuated vaccine against serotype 2 (VDV-2), or the...” PMID 25483647 2014

“This study evaluated the safety and immunogenicity of a candidate recombinant, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in 9-16 year olds in Latin America.” PMID 24067553 Oct 2013

“Immunogenicity and safety of a recombinant, live-attenuated, tetravalent dengue disease vaccine (CYD-TDV) was evaluated in children/adolescents in Brazil.” PMID 24189367 Nov 2013

“The recombinant yellow fever-17D-dengue virus, live, attenuated, tetravalent dengue vaccine (CYD-TDV) has undergone extensive clinical trials.” PMID 26279339 Aug 2015

“We evaluated the immunogenicity and safety of recombinant, live-attenuated, tetravalent dengue vaccine (CYD-TDV) in Indian adults.” PMID 26291554 2016

“The live attenuated tetravalent dengue vaccine (CYD-TDV) is licensed using a 0-, 6- and 12-month schedule in dengue-endemic areas.” PMID 30241510 Sep 2018

“We evaluated the safety and immunogenicity of Phase III lots of a candidate vaccine (CYD-TDV) in children in Malaysia.” PMID 24135573 Oct 2013

“receive three injections of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV), or placebo” PMID 25018116 Jul 2014

“receive three injections of recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) or placebo” PMID 25365753 Nov 2014

Known as CYD dengue vaccine “The aim of the study was to assess the efficacy of Sanofi Pasteur's CYD dengue vaccine in preventing symptomatic virologically-confirmed dengue cases for dengue-endemic areas...” NCT01374516
1

“The aim of the trial was to assess the efficacy of the CYD dengue vaccine in preventing symptomatic, virologically-confirmed dengue (VCD) cases.” NCT01373281

Known as Dengvaxia “The tetravalent dengue vaccine (CYD-TDV; Dengvaxia®) is administered on a three-dose schedule, 6 months apart in those aged ≥9 years in a number of dengue-endemic countries in...” PMID 31464558 Nov 2019
2

“Two large pivotal phase III studies demonstrated the efficacy of the tetravalent dengue vaccine (CYD-TDV; Dengvaxia®, Sanofi Pasteur) against all dengue serotypes.” PMID 28598256 Jun 2017

“vaccination with the tetravalent dengue vaccine (CYD-TDV; Dengvaxia) may bias the diagnosis of dengue” PMID 29300876 Apr 2018

Modality Vaccine “tetravalent CYD vaccinePMID 25483647 2014
Route Subcutaneous “0.5 mL, Subcutaneous (SC)” NCT00740155