drugset
Drugs / Mefenamic acid
last change Jan 2026 re-read 2 minutes ago

Mefenamic acid

also known as Acide mefenamique · Acido mefenamico · CI-473 · CN-35355 · Contraflam · Dysman-250 · Dysman-500 · Gardan · +19 more

Small molecule

Developed for
primary dysmenorrhea · uterine disorder · uterine anomalies
Investigated by
Albert Einstein College of Medicine · Bayer · Emalex Biosciences Inc. · H. Lundbeck A/S · Hanan Nabil · Mahidol University
+6 more · Nuventra, Inc. · Sanofi · Siriraj Hospital · Syneos Health · Takeda · University of Khartoum

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) PONSTEL — 1967-03-28 fda.gov ↗

Trials 9 · a red edge is where a trial was stopped

today
US approved 1967
NCT06277609 · Ph 1 NCT05064449 · Ph 1 NCT04902105 · Ph 1 NCT03383133 · Ph 0 NCT03323671 · Ph 2/3 NCT03070678 · Ph 1 NCT02417337 · Ph 2 NCT01295294 · Ph 4 NCT01060696 · not/applicable
196619671968196919701971197219731974197519761977197819791980198119821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03383133 Jan 2018 → Feb 2023 — Albert Einstein College of Medicine Completed No outcome recorded
Phase 14 trials
Phase 1 NCT06277609 Feb → May 2024 — H. Lundbeck A/S Completed No outcome recorded
Phase 1 NCT05064449 Oct → Nov 2021 — Takeda Completed No outcome recorded
Phase 1 NCT04902105 May → Jul 2021 — Emalex Biosciences Inc. Completed No outcome recorded
Phase 1 NCT03070678 Mar → Apr 2017 diabetes mellitus Sanofi Completed No outcome recorded
Phase 21 trial
Phase 2 NCT02417337 Aug 2012 → Aug 2014 pulpitis University of Khartoum Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT03323671 Aug → Dec 2017 primary dysmenorrhea Hanan Nabil Completed No outcome recorded
Phase 41 trial
Phase 4 NCT01295294 Mar → Dec 2011 uterine disorder Bayer Completed No outcome recorded
Phase not applicable1 trial
— NCT01060696 Jan 2009 → Mar 2010 female infertility Mahidol University Unknown No outcome recorded
Also used as a comparator or background therapy in 6 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT02183025 Comparator Jan 1998 → Apr 1999 primary dysmenorrhea Boehringer Ingelheim Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT01942122 Comparator Oct 2015 → Feb 2021 ovarian endometriosis Dexa Medica Group Completed No outcome recorded
Phase 31 trial
Phase 3 NCT02943655 Comparator Nov 2017 → Oct 2020 — Assiut University Completed No outcome recorded
Phase 42 trials
Phase 4 NCT07466342 Background Jul 2025 → Jan 2026 primary dysmenorrhea Nishtar Medical University Completed No outcome recorded
Phase 4 NCT01598012 Background Dec 2011 → Jul 2013 primary dysmenorrhea Mahidol University Completed No outcome recorded
Phase not applicable1 trial
— NCT06369012 Comparator Mar → Sep 2024 uterine anomalies Egymedicalpedia Completed No outcome recorded

Evidence & citations 31 cited values

Every value below carries the sentence it was read from. 16 sources stand behind the page.

FieldValueCited text
Known as Mefenamic acid “a single, oral, therapeutic dose of mefenamic acid (MEF, 0.75 g)” NCT03383133 ↗
14

NCT07466342 ↗

NCT03070678 ↗

NCT06277609 ↗

NCT02183025 ↗

NCT06369012 ↗

NCT01598012 ↗

NCT01060696 ↗

NCT01942122 ↗

NCT05064449 ↗

NCT04902105 ↗

NCT01295294 ↗

NCT03323671 ↗

NCT02417337 ↗

NCT02943655 ↗
Known as Acide mefenamique ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Acido mefenamico ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as CI-473 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as CN-35355 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Contraflam ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Dysman-250 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Dysman-500 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Gardan ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as INF-3355 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as J2.344B ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as M01AG01 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as MEF “mefenamic acid (MEF, 0.75 g)” NCT03383133 ↗
Known as Mefenamate ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Mefenaminic acid ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Meflam 250 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Meflam 500 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Mendys ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Mephenamic acid ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Mephenaminic acid ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as NSC-94437 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Opustan 250 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Opustan 500 ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Ponstan ChEMBL registry synonym — accepted as the source's own label CHEMBL686 ↗
Known as Ponstan (Mefenamic acid) “Ponstan (Mefenamic acid)” NCT01060696 ↗