Drugs / Padeliporfin
Padeliporfin
also known as
WST-11 · TOOKAD Soluble · Padeliporfin di-potassium · PADELIPORFIN POTASSIUM · Padeliporfin VTP · Padeliporfina · Padeliporfine · STAKEL · +3 more
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | EU (EMA) | Tookad | — | 2017-11-10 | europa.eu ↗ |
Trials 13
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 14 trials | ||||||
| Phase 1 | NCT05918783 | May 2025 → May 2027 expected | lung neoplasm | Impact Biotech Ltd | Recruiting | No outcome recorded |
| Phase 1 | NCT05919238 | May 2024 → May 2026 overdue | pancreatic adenocarcinoma | Impact Biotech Ltd | Recruiting | No outcome recorded |
| Phase 1 | NCT03617003 | Aug 2018 → Jul 2025 | renal pelvis/ureter urothelial carcinoma | Memorial Sloan Kettering Cancer Center | Completed | No outcome recorded |
| Phase 1 | NCT03133650 | Apr 2017 → Feb 2027 expected | gastroesophageal cancer | Memorial Sloan Kettering Cancer Center | Active not recruiting | No outcome recorded |
| Phase 1/22 trials | ||||||
| Phase 1/2 | NCT01573156 | May 2013 → May 2014 | kidney cancer | University of Oxford | Terminated | No outcome recorded |
| Phase 1/2 | NCT00946881 | Jul 2009 → Jul 2012 | prostate cancer | Steba Biotech S.A. | Completed | No outcome recorded |
| Phase 25 trials | ||||||
| Phase 2 | NCT01021956 | Jun 2010 → May 2012 | choroidal neovascularization, macular degeneration | Steba Biotech S.A. | Terminated | No outcome recorded |
| Phase 2 | NCT00974662 | Sep 2009 → Nov 2010 | non-small cell lung carcinoma | Steba Biotech S.A. | Terminated | No outcome recorded |
| Phase 2 | NCT00975429 | Sep 2009 → Dec 2011 | prostate cancer | Steba Biotech S.A. | Completed | No outcome recorded |
| Phase 2 | NCT00975039 | Sep 2009 → Jun 2011 | cholangiocarcinoma | Steba Biotech S.A. | Terminated | No outcome recorded |
| Phase 2 | NCT00707356 | Sep 2008 → Jan 2011 | prostate cancer | Steba Biotech S.A. | Completed | No outcome recorded |
| Phase 32 trials · 1 met primary | ||||||
| Phase 3 | NCT04620239 | Mar 2021 → Mar 2026 overdue | renal pelvis/ureter urothelial carcinoma | Steba Biotech S.A. | Recruiting | No outcome recorded |
| Phase 3 | NCT01310894 | Feb 2011 → Jun 2015 | prostate cancer | Steba Biotech S.A. | Completed | Met primary |
Evidence & citations 14 cited values
Every value below carries the sentence it was read from. 16 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Padeliporfin | “4 mg/kg padeliporfin intravenously over 10 min” PMID 28007457 ↗ Dec 2016 |
| Known as | Padeliporfin di-potassium | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594284 ↗ |
| Known as | PADELIPORFIN POTASSIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594284 ↗ |
| Known as | Padeliporfin VTP | “Padeliporfin VTP” NCT05918783 ↗ |
| Known as | Padeliporfina | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594284 ↗ |
| Known as | Padeliporfine | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594284 ↗ |
| Known as | STAKEL | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01021956 ↗ |
| Known as | TOOKAD | “TOOKAD (Padeliporfin) Vascular Targeted Photodynamic Therapy” NCT04620239 ↗ |
| Known as | TOOKAD Soluble | “using WST11 (TOOKAD Soluble) for vascular-targeted photodynamic (VTP) therapy” PMID 24841929 ↗ Apr 20151“WST11 - 4mg (TOOKAD® Soluble)” NCT00975429 ↗ |
| Known as | WST-11 | “Administration of WST11 in conjunction with endoscopic illumination at 753 nm emitted by a diode laser and administered to the participant by optical fibre catheters...” NCT03133650 ↗8“Vascular targeted photodynamic therapy with WST11 (TOOKAD® Soluble) is a form of tissue ablation” PMID 27291652 ↗ Jun 2016 “using Padeliporfin (WST-11) activated via endovascular fiber placement” NCT05919238 ↗ |
| Known as | WST-11 DIPOTASSIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594284 ↗ |
| Known as | WST11 POTASSIUM | ChEMBL registry synonym — accepted as the source's own label CHEMBL4594284 ↗ |
| Modality | Other / unclassified | “destroys targeted tissues using a photosensitizer [TOOKAD(®) Soluble (WST11), STEBA Biotech] activated by laser light in the presence of oxygen” PMID 25786708 ↗ Mar 2015 |
| Route | Intravenous | “WST11 was given as a 10-min intravenous infusion” PMID 24841929 ↗ Apr 2015 |