Drugs / Urapidil
last change Jun 2026 re-read 9 days ago

Urapidil

Small molecule

Developed for
brain ischemia · intracerebral hemorrhage · ischemic stroke · preeclampsia · stroke disorder
Investigated by
Second Affiliated Hospital, School of Medicine, Zhejiang University · Central Hospital, Nancy, France · Chinese PLA General Hospital · Department of Biostatistics, Southern Medical University · Fifth Affiliated Hospital, Sun Yat-Sen University · First Affiliated Hospital of Chengdu Medical College
+21 more · First Affiliated Hospital of Kunming Medical University · First Affiliated Hospital of Xinjiang Medical University · Guangdong 999 Brain Hospital · Henan Provincial People's Hospital · Hong Yang · LanZhou University · Maoming People's Hospital · People's Hospital of Guangxi Zhuang Autonomous Region · Qilu Hospital of Shandong University · Second Affiliated Hospital of Third Military Medical University · Shanghai East Hospital, China · Shenzhen Second People's Hospital · Sichuan Academy of Medical Sciences · The Fifth Affiliated Hospital of Southern Medical University · The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine · The George Institute for Global Health, China · The Second Hospital University of South China · University Hospital Schleswig-Holstein · University Hospital, Strasbourg, France · Xuanwu Hospital, Beijing · Zhongshan People's Hospital, Guangdong, China

Trials 8

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 34 trials · 1 missed
Phase 3 NCT06863558 May 2025 → Mar 2026 overdue intracerebral hemorrhage Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 3 NCT06863571 Apr 2025 → Mar 2026 overdue ischemic stroke Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting No outcome recorded
Phase 3 NCT03790800 Mar 2020 → Nov 2023 stroke disorder The George Institute for Global Health, China Completed Missed primary
Phase 3 NCT02558023 Sep 2015 → Aug 2020 preeclampsia University Hospital, Strasbourg, France Terminated No outcome recorded
Phase not applicable4 trials · 1 met primary
— NCT03497351 Apr 2018 → Jan 2019 — Chinese PLA General Hospital Completed No outcome recorded
— NCT03207100 Dec 2017 → Feb 2021 — Hong Yang Completed No outcome recorded
— NCT02116868 Mar 2014 → Mar 2018 — Central Hospital, Nancy, France Completed Met primary
— NCT01311414 — brain ischemia University Hospital Schleswig-Holstein Withdrawn No outcome recorded
Comparator or background therapy10 trials
Phase 1 NCT03001739 Background Dec 2016 → Dec 2018 aortic disorder, hypertensive disorder Sir Run Run Shaw Hospital Unknown No outcome recorded
Phase 2 NCT05670028 Background Jun 2023 → Jan 2026 ischemic stroke, vascular insufficiency disorder Beijing Tiantan Hospital Unknown No outcome recorded
Phase 3 NCT06677970 Comparator Oct 2024 → Dec 2029 expected ischemic stroke Yonsei University Recruiting No outcome recorded
Phase 3 NCT00409253 Comparator Jun 2007 → Jun 2010 preeclampsia University Hospital, Strasbourg, France Unknown No outcome recorded
Phase 4 NCT03529149 Background Apr 2018 → Jun 2019 ischemic stroke Xuanwu Hospital, Beijing Unknown No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as urapidil “To manipulate the blood pressure within a certain range with hypotensive drugs (e.g. nifedipine, benidipine, captopril, benazepril, irbesartan, labetalol, urapidil) and/or...” NCT05670028 ↗
17

“Terazosin (no less than 1 mg orally or via nasogastric tube, nightly) or Urapidil (100 mg in 30 mL saline, IV infusion at no less than 2 mL/h)” NCT06863558 ↗

“rescue intravenous antihypertensive medication using 10 mcg of urapidil will be administered by anaesthesiologist” NCT04500249 ↗

“Urapidil (100 mg in 30 mL saline, IV infusion at no less than 2 mL/h)” NCT06863571 ↗

“Urapidil, nicardipine, and labetalol will be used in this group.” NCT03207100 ↗

“Urapidil” NCT02116868 ↗

NCT03529149 ↗

NCT02558023 ↗

NCT03497351 ↗

NCT02857153 ↗

NCT01311414 ↗

Show 7 more sources

Known as Ebrantil ChEMBL registry synonym — accepted as the source's own label CHEMBL279229 ↗
Known as Ebrantil 25 “urapidil (Ebrantil 25, Takeda PHARMA, Japan) in a dose of 10 mg will be administered intravenously” NCT06609993 ↗
Known as Eupressyl\* “Urapidil (Eupressyl\*) : IV One initial iv bolus of 12.5 mg.” NCT02558023 ↗
1

“URAPIDIL (EUPRESSYL*)” NCT00409253 ↗

Known as NSC-310405 ChEMBL registry synonym — accepted as the source's own label CHEMBL279229 ↗
Known as URAPIDIL HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL279229 ↗
Modality Small molecule — CHEMBL279229 ↗
Route Intravenous “Urapidil (Eupressyl*) :IV” NCT00409253 ↗