Drugs / Urapidil
last change Jun 2026 re-read 2 minutes ago

Urapidil

Small molecule

Developed for
brain ischemia · intracerebral hemorrhage · ischemic stroke · preeclampsia · stroke disorder
Investigated by
Second Affiliated Hospital, School of Medicine, Zhejiang University · Central Hospital, Nancy, France · Chinese PLA General Hospital · Department of Biostatistics, Southern Medical University · Fifth Affiliated Hospital, Sun Yat-Sen University · First Affiliated Hospital of Chengdu Medical College
+21 more · First Affiliated Hospital of Kunming Medical University · First Affiliated Hospital of Xinjiang Medical University · Guangdong 999 Brain Hospital · Henan Provincial People's Hospital · Hong Yang · LanZhou University · Maoming People's Hospital · People's Hospital of Guangxi Zhuang Autonomous Region · Qilu Hospital of Shandong University · Second Affiliated Hospital of Third Military Medical University · Shanghai East Hospital, China · Shenzhen Second People's Hospital · Sichuan Academy of Medical Sciences · The Fifth Affiliated Hospital of Southern Medical University · The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine · The George Institute for Global Health, China · The Second Hospital University of South China · University Hospital Schleswig-Holstein · University Hospital, Strasbourg, France · Xuanwu Hospital, Beijing · Zhongshan People's Hospital, Guangdong, China

Trials 8 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 34 trials
Phase 3 NCT06863558 May 2025 → Mar 2026 overdue intracerebral hemorrhage Second Affiliated Hospital, School of Medicine, Zhejiang University Not yet recruiting No outcome recorded
Phase 3 NCT06863571 Apr 2025 → Mar 2026 overdue ischemic stroke Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting No outcome recorded
Phase 3 NCT03790800 Mar 2020 → Nov 2023 stroke disorder The George Institute for Global Health, China Completed No outcome recorded
Phase 3 NCT02558023 Sep 2015 → Aug 2020 preeclampsia University Hospital, Strasbourg, France Terminated No outcome recorded
Phase not applicable4 trials
NCT03497351 Apr 2018 → Jan 2019 Chinese PLA General Hospital Completed No outcome recorded
NCT03207100 Dec 2017 → Feb 2021 Hong Yang Completed No outcome recorded
NCT02116868 Mar 2014 → Mar 2018 Central Hospital, Nancy, France Completed No outcome recorded
NCT01311414 brain ischemia University Hospital Schleswig-Holstein Withdrawn No outcome recorded
Also used as a comparator or background therapy in 10 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 11 trial
Phase 1 NCT03001739 Background Dec 2016 → Dec 2018 aortic disorder, hypertensive disorder Sir Run Run Shaw Hospital Unknown No outcome recorded
Phase 21 trial
Phase 2 NCT05670028 Background Jun 2023 → Jan 2026 ischemic stroke, vascular insufficiency disorder Beijing Tiantan Hospital Unknown No outcome recorded
Phase 32 trials
Phase 3 NCT06677970 Comparator Oct 2024 → Dec 2029 expected ischemic stroke Yonsei University Recruiting No outcome recorded
Phase 3 NCT00409253 Comparator Jun 2007 → Jun 2010 preeclampsia University Hospital, Strasbourg, France Unknown No outcome recorded
Phase 42 trials
Phase 4 NCT03529149 Background Apr 2018 → Jun 2019 ischemic stroke Xuanwu Hospital, Beijing Unknown No outcome recorded
Phase 4 NCT03300479 Comparator Jun 2017 → May 2021 intracerebral hemorrhage University of Zurich Withdrawn No outcome recorded
Phase not applicable4 trials
NCT06609993 Background Dec 2017 → Mar 2020 abdominal aortic aneurysm Michał Stasiowski Completed No outcome recorded
NCT02857153 Background Jul 2016 → Jul 2017 delirium Hu Anmin Unknown No outcome recorded
NCT04500249 Background Oct 2015 → Oct 2020 carotid stenosis Medical University of Silesia Unknown No outcome recorded
NCT00226096 Background Nov 2005 → Sep 2007 intracerebral hemorrhage The George Institute Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 19 sources stand behind the page.

FieldValueCited text
Known as Urapidil “To manipulate the blood pressure within a certain range with hypotensive drugs (e.g. nifedipine, benidipine, captopril, benazepril, irbesartan, labetalol, urapidil) and/or...” NCT05670028
17

“Terazosin (no less than 1 mg orally or via nasogastric tube, nightly) or Urapidil (100 mg in 30 mL saline, IV infusion at no less than 2 mL/h)” NCT06863558

“rescue intravenous antihypertensive medication using 10 mcg of urapidil will be administered by anaesthesiologist” NCT04500249

Urapidil (100 mg in 30 mL saline, IV infusion at no less than 2 mL/h)” NCT06863571

Urapidil, nicardipine, and labetalol will be used in this group.” NCT03207100

UrapidilNCT02116868

NCT03300479

NCT06609993

NCT03529149

NCT03790800

NCT00409253

NCT02558023

NCT00226096

NCT02857153

NCT06677970

NCT03001739

NCT03497351

NCT01311414

Known as Ebrantil ChEMBL registry synonym — accepted as the source's own label CHEMBL279229
Known as Ebrantil 25 “urapidil (Ebrantil 25, Takeda PHARMA, Japan) in a dose of 10 mg will be administered intravenously” NCT06609993
Known as EUPRESSYL* “Urapidil (Eupressyl\*) : IV One initial iv bolus of 12.5 mg.” NCT02558023
1

“URAPIDIL (EUPRESSYL*)” NCT00409253

Known as NSC-310405 ChEMBL registry synonym — accepted as the source's own label CHEMBL279229
Known as URAPIDIL HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL279229
Modality Small molecule CHEMBL279229
Route Intravenous “Urapidil (Eupressyl*) :IV” NCT00409253